STAB2

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Stabilin 2
Identifiers
Symbols STAB2 ; FEEL2; FELE-2; FELL2; FEX2; HARE
External IDs OMIM608561 MGI2178743 HomoloGene23022 GeneCards: STAB2 Gene
Orthologs
Species Human Mouse
Entrez 55576 192188
Ensembl ENSG00000136011 ENSMUSG00000035459
UniProt Q8WWQ8 Q8R4U0
RefSeq (mRNA) NM_017564 NM_138673
RefSeq (protein) NP_060034 NP_619614
Location (UCSC) Chr 12:
103.98 – 104.16 Mb
Chr 10:
86.84 – 87.01 Mb
PubMed search [1] [2]

Stabilin-2 is a protein that in humans is encoded by the STAB2 gene.[1][2][3]

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.[3]

References[edit]

  1. ^ Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S (Feb 2002). "Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues". Biochem J 362 (Pt 1): 155–64. doi:10.1042/0264-6021:3620155. PMC 1222372. PMID 11829752. 
  2. ^ Adachi H, Tsujimoto M (Sep 2002). "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities". J Biol Chem 277 (37): 34264–70. doi:10.1074/jbc.M204277200. PMID 12077138. 
  3. ^ a b "Entrez Gene: STAB2 stabilin 2". 

Further reading[edit]