This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.
^Adachi H, Tsujimoto M (Sep 2002). "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities". J Biol Chem277 (37): 34264–70. doi:10.1074/jbc.M204277200. PMID12077138.
Tamura Y, Adachi H, Osuga J et al. (2003). "FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products". J. Biol. Chem.278 (15): 12613–7. doi:10.1074/jbc.M210211200. PMID12473645.
Zhou B, McGary CT, Weigel JA et al. (2004). "Purification and molecular identification of the human hyaluronan receptor for endocytosis". Glycobiology13 (5): 339–49. doi:10.1093/glycob/cwg029. PMID12626425.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Harris EN, Weigel JA, Weigel PH (2004). "Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE)". J. Biol. Chem.279 (35): 36201–9. doi:10.1074/jbc.M405322200. PMID15208308.
Hansen B, Longati P, Elvevold K et al. (2005). "Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding". Exp. Cell Res.303 (1): 160–73. doi:10.1016/j.yexcr.2004.09.017. PMID15572036.
Harris EN, Kyosseva SV, Weigel JA, Weigel PH (2007). "Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE)". J. Biol. Chem.282 (5): 2785–97. doi:10.1074/jbc.M607787200. PMID17145755.