Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5Agene.STAT5Aorthologs have been identified in several placentals for which complete genome data are available.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
^Hou J, Schindler U, Henzel WJ, Wong SC, McKnight SL (May 1995). "Identification and purification of human Stat proteins activated in response to interleukin-2". Immunity2 (4): 321–9. doi:10.1016/1074-7613(95)90140-X. PMID7719937.
^Lin JX, Mietz J, Modi WS, John S, Leonard WJ (July 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J Biol Chem271 (18): 10738–44. doi:10.1074/jbc.271.18.10738. PMID8631883.
^Ota, J; Kimura F, Sato K, Wakimoto N, Nakamura Y, Nagata N, Suzu S, Yamada M, Shimamura S, Motoyoshi K (November 1998). "Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin". Biochem. Biophys. Res. Commun. (UNITED STATES) 252 (3): 779–86. doi:10.1006/bbrc.1998.9445. ISSN0006-291X. PMID9837784.
^Olayioye, M A; Beuvink I, Horsch K, Daly J M, Hynes N E (June 1999). "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". J. Biol. Chem. (UNITED STATES) 274 (24): 17209–18. doi:10.1074/jbc.274.24.17209. ISSN0021-9258. PMID10358079.
^Williams, Christopher C; Allison June G, Vidal Gregory A, Burow Matthew E, Beckman Barbara S, Marrero Luis, Jones Frank E (November 2004). "The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone". J. Cell Biol. (United States) 167 (3): 469–78. doi:10.1083/jcb.200403155. ISSN0021-9525. PMC2172499. PMID15534001.
^Chin, H; Nakamura N, Kamiyama R, Miyasaka N, Ihle J N, Miura O (December 1996). "Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3". Blood (UNITED STATES) 88 (12): 4415–25. ISSN0006-4971. PMID8977232.
^ abFujitani, Y; Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene (ENGLAND) 14 (7): 751–61. doi:10.1038/sj.onc.1200907. ISSN0950-9232. PMID9047382.
^Pircher, T J; Petersen H, Gustafsson J A, Haldosén L A (April 1999). "Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a". Mol. Endocrinol. (UNITED STATES) 13 (4): 555–65. doi:10.1210/me.13.4.555. ISSN0888-8809. PMID10194762.
^Dinerstein-Cali, H; Ferrag F, Kayser C, Kelly P A, Postel-Vinay M (August 2000). "Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins". Mol. Cell. Endocrinol. (IRELAND) 166 (2): 89–99. doi:10.1016/S0303-7207(00)00277-X. ISSN0303-7207. PMID10996427.
^Chughtai, Naila; Schimchowitsch Sarah, Lebrun Jean-Jacques, Ali Suhad (August 2002). "Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells". J. Biol. Chem. (United States) 277 (34): 31107–14. doi:10.1074/jbc.M200156200. ISSN0021-9258. PMID12060651.