Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5Agene.STAT5Aorthologs have been identified in several placentals for which complete genome data are available.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
^Hou J, Schindler U, Henzel WJ, Wong SC, McKnight SL (May 1995). "Identification and purification of human Stat proteins activated in response to interleukin-2". Immunity2 (4): 321–9. doi:10.1016/1074-7613(95)90140-X. PMID7719937.
^Lin JX, Mietz J, Modi WS, John S, Leonard WJ (July 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J Biol Chem271 (18): 10738–44. doi:10.1074/jbc.271.18.10738. PMID8631883.
^Olayioye, M A; Beuvink I; Horsch K; Daly J M; Hynes N E (June 1999). "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". J. Biol. Chem. (UNITED STATES) 274 (24): 17209–18. doi:10.1074/jbc.274.24.17209. ISSN0021-9258. PMID10358079.
^Chin, H; Nakamura N; Kamiyama R; Miyasaka N; Ihle J N; Miura O (December 1996). "Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3". Blood (UNITED STATES) 88 (12): 4415–25. ISSN0006-4971. PMID8977232.
^ abFujitani, Y; Hibi M; Fukada T; Takahashi-Tezuka M; Yoshida H; Yamaguchi T; Sugiyama K; Yamanaka Y; Nakajima K; Hirano T (February 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene (ENGLAND) 14 (7): 751–61. doi:10.1038/sj.onc.1200907. ISSN0950-9232. PMID9047382.
^Chughtai, Naila; Schimchowitsch Sarah; Lebrun Jean-Jacques; Ali Suhad (August 2002). "Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells". J. Biol. Chem. (United States) 277 (34): 31107–14. doi:10.1074/jbc.M200156200. ISSN0021-9258. PMID12060651.