STAT5B

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Signal transducer and activator of transcription 5B
Protein STAT5B PDB 1y1u.png
PDB rendering based on 1y1u.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols STAT5B ; STAT5
External IDs OMIM604260 MGI103035 HomoloGene55718 ChEMBL: 5817 GeneCards: STAT5B Gene
RNA expression pattern
PBB GE STAT5B 205026 at tn.png
PBB GE STAT5B 212549 at tn.png
PBB GE STAT5B 212550 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6777 20851
Ensembl ENSG00000173757 ENSMUSG00000020919
UniProt P51692 P42232
RefSeq (mRNA) NM_012448 NM_001113563
RefSeq (protein) NP_036580 NP_001107035
Location (UCSC) Chr 17:
40.35 – 40.43 Mb
Chr 11:
100.78 – 100.85 Mb
PubMed search [1] [2]

Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene.[1] STAT5B orthologs [2] have been identified in most placentals for which complete genome data are available.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APML). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML.[3]

Interactions[edit]

STAT5B has been shown to interact with PTPN11,[4] Janus kinase 2,[5][6] Janus kinase 1[6] and Glucocorticoid receptor.[7]

See also[edit]

References[edit]

  1. ^ Lin JX, Mietz J, Modi WS, John S, Leonard WJ (July 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J Biol Chem 271 (18): 10738–44. doi:10.1074/jbc.271.18.10738. PMID 8631883. 
  2. ^ "OrthoMaM phylogenetic marker: STAT5B coding sequence". 
  3. ^ "Entrez Gene: STAT5B signal transducer and activator of transcription 5B". 
  4. ^ Yu, C L; Jin Y J; Burakoff S J (January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation". J. Biol. Chem. (UNITED STATES) 275 (1): 599–604. doi:10.1074/jbc.275.1.599. ISSN 0021-9258. PMID 10617656. 
  5. ^ Barahmand-Pour, F; Meinke A; Groner B; Decker T (May 1998). "Jak2-Stat5 interactions analyzed in yeast". J. Biol. Chem. (UNITED STATES) 273 (20): 12567–75. doi:10.1074/jbc.273.20.12567. ISSN 0021-9258. PMID 9575217. 
  6. ^ a b Fujitani, Y; Hibi M; Fukada T; Takahashi-Tezuka M; Yoshida H; Yamaguchi T; Sugiyama K; Yamanaka Y; Nakajima K; Hirano T (February 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene (ENGLAND) 14 (7): 751–61. doi:10.1038/sj.onc.1200907. ISSN 0950-9232. PMID 9047382. 
  7. ^ Stöcklin, E; Wissler M; Gouilleux F; Groner B (October 1996). "Functional interactions between Stat5 and the glucocorticoid receptor". Nature (ENGLAND) 383 (6602): 726–8. doi:10.1038/383726a0. ISSN 0028-0836. PMID 8878484. 

Further reading[edit]

  • Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges.". Gene 285 (1-2): 1–24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.