STAT6

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Signal transducer and activator of transcription 6, interleukin-4 induced
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols STAT6 ; D12S1644; IL-4-STAT; STAT6B; STAT6C
External IDs OMIM601512 MGI103034 HomoloGene2373 ChEMBL: 5401 GeneCards: STAT6 Gene
RNA expression pattern
PBB GE STAT6 201331 s at tn.png
PBB GE STAT6 201332 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6778 20852
Ensembl ENSG00000166888 ENSMUSG00000002147
UniProt P42226 P52633
RefSeq (mRNA) NM_001178078 NM_009284
RefSeq (protein) NP_001171549 NP_033310
Location (UCSC) Chr 12:
57.49 – 57.53 Mb
Chr 10:
127.64 – 127.66 Mb
PubMed search [1] [2]

STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.[1][2]

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.[3]

Interactions[edit]

STAT6 has been shown to interact with EP300,[4] CREB-binding protein,[4][5] NFKB1,[6] Nuclear receptor coactivator 1,[5][7] IRF4[8] and SND1.[9]

Pathology[edit]

  • Amplification
    • STAT6 is amplified in a subset of dedifferentiated liposarcoma.[11]

See also[edit]

References[edit]

  1. ^ Leek JP, Hamlin PJ, Bell SM, Lench NJ (1997). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 208–9. doi:10.1159/000134723. PMID 9605853. 
  2. ^ Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL (September 1994). "An interleukin-4-induced transcription factor: IL-4 Stat". Science 265 (5179): 1701–6. doi:10.1126/science.8085155. PMID 8085155. 
  3. ^ "Entrez Gene: STAT6 signal transducer and activator of transcription 6, interleukin-4 induced". 
  4. ^ a b McDonald, C; Reich N C (July 1999). "Cooperation of the transcriptional coactivators CBP and p300 with Stat6". J. Interferon Cytokine Res. (UNITED STATES) 19 (7): 711–22. doi:10.1089/107999099313550. ISSN 1079-9907. PMID 10454341. 
  5. ^ a b Litterst, C M; Pfitzner E (Dec 2001). "Transcriptional activation by STAT6 requires the direct interaction with NCoA-1". J. Biol. Chem. (United States) 276 (49): 45713–21. doi:10.1074/jbc.M108132200. ISSN 0021-9258. PMID 11574547. 
  6. ^ Shen, C H; Stavnezer J (June 1998). "Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3395–404. ISSN 0270-7306. PMC 108921. PMID 9584180. 
  7. ^ Litterst, Claudia M; Pfitzner Edith (September 2002). "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1". J. Biol. Chem. (United States) 277 (39): 36052–60. doi:10.1074/jbc.M203556200. ISSN 0021-9258. PMID 12138096. 
  8. ^ Gupta, S; Jiang M; Anthony A; Pernis A B (Dec 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. (UNITED STATES) 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. ISSN 0022-1007. PMC 2195723. PMID 10601358. 
  9. ^ Yang, Jie; Aittomäki Saara; Pesu Marko; Carter Kara; Saarinen Jussi; Kalkkinen Nisse; Kieff Elliott; Silvennoinen Olli (September 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". EMBO J. (England) 21 (18): 4950–8. doi:10.1093/emboj/cdf463. ISSN 0261-4189. PMC 126276. PMID 12234934. 
  10. ^ Kabbinavar, F. F.; Hambleton, J; Mass, R. D.; Hurwitz, H. I.; Bergsland, E; Sarkar, S (2005). "Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer". Journal of Clinical Oncology 23 (16): 3706–12. doi:10.1200/JCO.2005.00.232. PMID 15867200.  edit
  11. ^ Doyle, L. A.; Tao, D; Mariño-Enríquez, A (2014). "STAT6 is amplified in a subset of dedifferentiated liposarcoma". Modern Pathology. doi:10.1038/modpathol.2013.247. PMID 24457460.  edit

Further reading[edit]

External links[edit]