STAU2

Staufen, RNA binding protein, homolog 2 (Drosophila)
PDB rendering based on 1uhz.
Available structures PDB 1uhz
Identifiers
Symbols	STAU2; 39K2; 39K3; DKFZp781K0371; MGC119606
External IDs	OMIM: 605920 MGI: 1352508 HomoloGene: 8666 GeneCards: STAU2 Gene
Gene Ontology Molecular function • double-stranded RNA binding Cellular component • intracellular • nucleus • nucleolus • cytoplasm • endoplasmic reticulum • microtubule Biological process • transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27067	29819
Ensembl	ENSG00000040341	ENSMUSG00000025920
UniProt	Q9NUL3	Q8CJ67
RefSeq (mRNA)	NM_001164380.1	NM_025303
RefSeq (protein)	NP_001157852.1	NP_079579
Location (UCSC)	Chr 8: 74.33 – 74.66 Mb	Chr 1: 16.22 – 16.51 Mb
PubMed search	[1]	[2]

Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene.

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.

Further reading

• Kiebler MA, DesGroseillers L (2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron 25 (1): 19–28. doi:10.1016/S0896-6273(00)80868-5. PMID 10707969. 
• Furic L, Maher-Laporte M, DesGroseillers L (2008). "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes". RNA 14 (2): 324–35. doi:10.1261/rna.720308. PMC 2212254. PMID 18094122. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2212254. 
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Chatel-Chaix L, Clément JF, Martel C, et al. (2004). "Identification of Staufen in the Human Immunodeficiency Virus Type 1 Gag Ribonucleoprotein Complex and a Role in Generating Infectious Viral Particles". Mol. Cell. Biol. 24 (7): 2637–48. doi:10.1128/MCB.24.7.2637-2648.2004. PMC 371130. PMID 15024055. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=371130. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Duchaîne TF, Hemraj I, Furic L, et al. (2003). "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles". J. Cell. Sci. 115 (Pt 16): 3285–95. PMID 12140260.