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Stanniocalcin 2
Symbols STC2 ; STC-2; STCRP
External IDs OMIM603665 MGI1316731 HomoloGene2753 GeneCards: STC2 Gene
RNA expression pattern
PBB GE STC2 203439 s at tn.png
PBB GE STC2 203438 at tn.png
More reference expression data
Species Human Mouse
Entrez 8614 20856
Ensembl ENSG00000113739 ENSMUSG00000020303
UniProt O76061 O88452
RefSeq (mRNA) NM_003714 NM_011491
RefSeq (protein) NP_003705 NP_035621
Location (UCSC) Chr 5:
172.74 – 172.76 Mb
Chr 11:
31.36 – 31.37 Mb
PubMed search [1] [2]

Stanniocalcin-2 is a protein that in humans is encoded by the STC2 gene.[1][2][3]

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.[3]


  1. ^ Chang AC, Reddel RR (Nov 1998). "Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2". Mol Cell Endocrinol 141 (1–2): 95–9. doi:10.1016/S0303-7207(98)00097-5. PMID 9723890. 
  2. ^ Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, Imai M (Nov 1998). "Molecular cloning of a second human stanniocalcin homologue (STC2)". Biochem Biophys Res Commun 250 (2): 252–8. doi:10.1006/bbrc.1998.9300. PMID 9753616. 
  3. ^ a b "Entrez Gene: STC2 stanniocalcin 2". 

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