STS-135 (drug)

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STS-135 structure.png
Systematic (IUPAC) name
Clinical data
Chemical data
Formula C24H31FN2O
382.51 g/mol

STS-135 (N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA) is a designer drug offered by online vendors as a cannabimimetic agent. The structure of STS-135 appears to utilise an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear.[1] STS-135 is the terminally-fluorinated analogue of SDB-001, just as AM-2201 is the terminally-fluorinated analogue of JWH-018, and XLR-11 is the terminally-fluorinated analogue of UR-144. No information regarding the in vitro or in vivo activity of STS-135 has been published, and only anecdotal reports are known of its pharmacology in humans or other animals.


A forensic standard of STS-135 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[2]

See also[edit]


  1. ^ Wilkinson, S. M.; Banister, S. D.; Kassiou, M. (2015). "Bioisosteric Fluorine in the Clandestine Design of Synthetic Cannabinoids". Australian Journal of Chemistry 68: 4. doi:10.1071/CH14198.  edit
  2. ^ Southern Association of Forensic Scientists