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STUMP stands for stromal tumor of undetermined malignant potential. They are atypical smooth muscle tumors with low mitotic activity. the Bell criteria were developed to help categorize them by the degree of atypia, the mitotic figures, and necrosis.
- minimal: smooth nuclei, smooth contours, minimal variation in nuclear size, shape, and evenly distributed chromatin
- moderate: many large, plump, irregular nuclei, 1-2 mitotic figures
- severe: obvious pleomorphism, enlarged bizarre nuclei with dense chromatin, giant cells, often multinucleated, enlarged, atypical nucleoli
Evaluation of the mitotic figures in a STUMP requires evaluation of 3 specific criteria
- Hairy extensions of chromatin must be present, extending from a central clot-like dense mass of chromosomes. Hairy extensions from an empty center favor a non-mitosis. Count 4 sets of 10 fields in the area of highest mitotic activity and use the highest count
- No nuclear membrane
- Rule out lymphocytes, mast cells, stripped nuclei, degenerated cells, and precipitated hematoxylin.
Coagulative tumor cell necrosis is common in clinically malignant smooth muscle cell tumors. It consists of an abrupt transition between necrotic cells and preserved cells. Ghost nuclei from necrotic cells are often see, but inflammatory cells are uncommon. Hyalinizing necrosis is more common in leiomyomas. It consists of a zone of hyalinized collagen between dead cells and preserved cells, commonly eosinophilic. If dead nuclei present, they are uniform and the chromatin is often. Necrosis secondary to ulceration in submucous leiomyomas features acute inflammatory cells and a peripheral reparative process, whereas ghost outlines of nuclei are usually inconspicuous or absent.
- Bell's criteria do not apply to extrauterine tumors
- No or mild atypia, no tumor cell necrosis ⇒ leiomyoma. If 5 or more mitotic figures are present in 10 high powered fields but the behavior still appears benign, may append “with significant mitotic activity”.
- Moderate to severe atypia without tumor cell necrosis
- Moderate to severe atypia and tumor cell necrosis ⇒ leiomyosarcoma (mitotic figures don’t matter).
- Guntupalli SR, Ramirez PT, Anderson ML, Milam MR, Bodurka DC, Malpica A (June 2009). "Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis". Gynecol. Oncol. 113 (3): 324–6. doi:10.1016/j.ygyno.2009.02.020. PMID 19342083.
- Ng JS, Han A, Chew SH, Low J (August 2010). "A clinicopathologic study of uterine smooth muscle tumours of uncertain malignant potential (STUMP)" (PDF). Ann. Acad. Med. Singap. 39 (8): 625–8. PMID 20838704.
- Ip PP, Cheung AN, Clement PB (July 2009). "Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases". Am. J. Surg. Pathol. 33 (7): 992–1005. doi:10.1097/PAS.0b013e3181a02d1c. PMID 19417585.
- Chen WY, Yang AH, Liu HC (April 1991). "Spindle cell stromal tumors of gastrointestinal tract: a histological and immunohistochemical study". Zhonghua Yi Xue Za Zhi (Taipei) 47 (4): 219–27. PMID 1710946.
- [full citation needed] http://www.pathologyoutlines.com/topic/uterusSTUMP.html