STX2

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Syntaxin 2
Identifiers
Symbols STX2 ; EPIM; EPM; STX2A; STX2B; STX2C
External IDs OMIM132350 MGI108059 HomoloGene37559 GeneCards: STX2 Gene
RNA expression pattern
PBB GE STX2 213434 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2054 13852
Ensembl ENSG00000111450 ENSMUSG00000029428
UniProt P32856 D3YY94
RefSeq (mRNA) NM_001980 NM_001286033
RefSeq (protein) NP_001971 NP_001272962
Location (UCSC) Chr 12:
131.27 – 131.32 Mb
Chr 5:
128.98 – 129.01 Mb
PubMed search [1] [2]

Syntaxin-2 is a protein that in humans is encoded by the STX2 gene.[1][2][3]

The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

Interactions[edit]

STX2 has been shown to interact with SNAP-25,[4][5] SNAP23,[5][6][7][8] STXBP1[4][9] and Syntaxin binding protein 3.[9]

References[edit]

  1. ^ Zha H, Remmers EF, Szpirer C, Szpirer J, Zhang H, Kozak CA, Wilder RL (Mar 1997). "The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12". Genomics 37 (3): 386–9. doi:10.1006/geno.1996.0574. PMID 8938452. 
  2. ^ Band AM, Kuismanen E (Jun 2005). "Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments". BMC Cell Biol 6: 26. doi:10.1186/1471-2121-6-26. PMC 1156879. PMID 15943887. 
  3. ^ a b "Entrez Gene: STX2 syntaxin 2". 
  4. ^ a b Hata, Y; Südhof T C (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. (UNITED STATES) 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. ISSN 0021-9258. PMID 7768895. 
  5. ^ a b Ravichandran, V; Chawla A; Roche P A (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. (UNITED STATES) 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. ISSN 0021-9258. PMID 8663154. 
  6. ^ Imai, Akane; Nashida Tomoko; Yoshie Sumio; Shimomura Hiromi (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. (England) 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. ISSN 0003-9969. PMID 12828989. 
  7. ^ Li, Guangmu; Alexander Edward A; Schwartz John H (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". J. Biol. Chem. (United States) 278 (22): 19791–7. doi:10.1074/jbc.M212250200. ISSN 0021-9258. PMID 12651853. 
  8. ^ Araki, S; Tamori Y; Kawanishi M; Shinoda H; Masugi J; Mori H; Niki T; Okazawa H; Kubota T; Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. (UNITED STATES) 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. ISSN 0006-291X. PMID 9168999. 
  9. ^ a b Schraw, Todd D; Lemons Paula P; Dean William L; Whiteheart Sidney W (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. (England) 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. ISSN 0264-6021. PMC 1223584. PMID 12773094. 

Further reading[edit]