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Syntaxin 4
Symbols STX4 ; STX4A; p35-2
External IDs OMIM186591 MGI893577 HomoloGene105435 GeneCards: STX4 Gene
RNA expression pattern
PBB GE STX4 203530 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6810 20909
Ensembl ENSG00000103496 ENSMUSG00000030805
UniProt Q12846 P70452
RefSeq (mRNA) NM_001272095 NM_009294
RefSeq (protein) NP_001259024 NP_033320
Location (UCSC) Chr 16:
31.03 – 31.04 Mb
Chr 7:
127.82 – 127.85 Mb
PubMed search [1] [2]

Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.[1][2][3]


STX4 has been shown to interact with SNAP-25,[4][5][6][7] NAPA,[8] STXBP5,[9] SNAP23,[5][7][10][11][12][13][14][15] Vesicle-associated membrane protein 8,[13][16] RAB4A,[17] TXLNB,[18] VAMP2,[6][13][19][20] VAMP3,[8][10][13][16] STXBP1[4][21] and Syntaxin binding protein 3.[9][21]


  1. ^ Li H, Hodge DR, Pei GK, Seth A (July 1994). "Isolation and sequence analysis of the human syntaxin-encoding gene". Gene 143 (2): 303–4. doi:10.1016/0378-1119(94)90117-1. PMID 8206394. 
  2. ^ Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T (January 2006). "Syntaxins 3 and 4 Are Concentrated in Separate Clusters on the Plasma Membrane before the Establishment of Cell Polarity". Mol Biol Cell 17 (2): 977–89. doi:10.1091/mbc.E05-05-0462. PMC 1356605. PMID 16339081. 
  3. ^ "Entrez Gene: STX4 Syntaxin 4". 
  4. ^ a b Hata, Y; Südhof T C (June 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. (UNITED STATES) 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. ISSN 0021-9258. PMID 7768895. 
  5. ^ a b Ravichandran, V; Chawla A; Roche P A (June 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. (UNITED STATES) 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. ISSN 0021-9258. PMID 8663154. 
  6. ^ a b Reed, G L; Houng A K; Fitzgerald M L (April 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood (UNITED STATES) 93 (8): 2617–26. ISSN 0006-4971. PMID 10194441. 
  7. ^ a b Steegmaier, M; Yang B; Yoo J S; Huang B; Shen M; Yu S; Luo Y; Scheller R H (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. (UNITED STATES) 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. ISSN 0021-9258. PMID 9852078. 
  8. ^ a b Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  9. ^ a b Widberg, Charlotte H; Bryant Nia J; Girotti Milena; Rea Shane; James David E (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. (United States) 278 (37): 35093–101. doi:10.1074/jbc.M304261200. ISSN 0021-9258. PMID 12832401. 
  10. ^ a b Imai, Akane; Nashida Tomoko; Yoshie Sumio; Shimomura Hiromi (August 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. (England) 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. ISSN 0003-9969. PMID 12828989. 
  11. ^ Li, Guangmu; Alexander Edward A; Schwartz John H (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". J. Biol. Chem. (United States) 278 (22): 19791–7. doi:10.1074/jbc.M212250200. ISSN 0021-9258. PMID 12651853. 
  12. ^ Araki, S; Tamori Y; Kawanishi M; Shinoda H; Masugi J; Mori H; Niki T; Okazawa H; Kubota T; Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. (UNITED STATES) 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. ISSN 0006-291X. PMID 9168999. 
  13. ^ a b c d Paumet, F; Le Mao J; Martin S; Galli T; David B; Blank U; Roa M (June 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". J. Immunol. (UNITED STATES) 164 (11): 5850–7. doi:10.4049/jimmunol.164.11.5850. ISSN 0022-1767. PMID 10820264. 
  14. ^ Kawanishi, M; Tamori Y; Okazawa H; Araki S; Shinoda H; Kasuga M (March 2000). "Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2". J. Biol. Chem. (UNITED STATES) 275 (11): 8240–7. doi:10.1074/jbc.275.11.8240. ISSN 0021-9258. PMID 10713150. 
  15. ^ Freedman, Steven J; Song Hyun Kyu, Xu Yingwu, Sun Zhen-Yu J, Eck Michael J (April 2003). "Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain". J. Biol. Chem. (United States) 278 (15): 13462–7. doi:10.1074/jbc.M210483200. ISSN 0021-9258. PMID 12556468. 
  16. ^ a b Polgár, János; Chung Sul-Hee; Reed Guy L (August 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood (United States) 100 (3): 1081–3. doi:10.1182/blood.V100.3.1081. ISSN 0006-4971. PMID 12130530. 
  17. ^ Li, L; Omata W; Kojima I; Shibata H (February 2001). "Direct interaction of Rab4 with syntaxin 4". J. Biol. Chem. (United States) 276 (7): 5265–73. doi:10.1074/jbc.M003883200. ISSN 0021-9258. PMID 11063739. 
  18. ^ Nogami, Satoru; Satoh Sachie, Tanaka-Nakadate Sawako, Yoshida Kenji, Nakano Michiko, Terano Akira, Shirataki Hiromichi (July 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. (United States) 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. ISSN 0006-291X. PMID 15184072. 
  19. ^ Mollinedo, Faustino; Martín-Martín Belén, Calafat Jero, Nabokina Svetlana M, Lazo Pedro A (January 2003). "Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary granules of human neutrophils". J. Immunol. (United States) 170 (2): 1034–42. doi:10.4049/jimmunol.170.2.1034. ISSN 0022-1767. PMID 12517971. 
  20. ^ Jagadish, M N; Fernandez C S, Hewish D R, Macaulay S L, Gough K H, Grusovin J, Verkuylen A, Cosgrove L, Alafaci A, Frenkel M J, Ward C W (August 1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". Biochem. J. (ENGLAND) 317 (Pt 3): 945–54. ISSN 0264-6021. PMC 1217577. PMID 8760387. 
  21. ^ a b Schraw, Todd D; Lemons Paula P; Dean William L; Whiteheart Sidney W (August 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. (England) 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. ISSN 0264-6021. PMC 1223584. PMID 12773094. 

Further reading[edit]