STXBP1

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Syntaxin binding protein 1
Protein STXBP1 PDB 1dn1.png
PDB rendering based on 1dn1.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols STXBP1 ; MUNC18-1; NSEC1; P67; RBSEC1; UNC18
External IDs OMIM602926 MGI107363 HomoloGene2382 GeneCards: STXBP1 Gene
RNA expression pattern
PBB GE STXBP1 202260 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6812 20910
Ensembl ENSG00000136854 ENSMUSG00000026797
UniProt P61764 O08599
RefSeq (mRNA) NM_001032221 NM_001113569
RefSeq (protein) NP_001027392 NP_001107041
Location (UCSC) Chr 9:
130.37 – 130.46 Mb
Chr 2:
32.79 – 32.85 Mb
PubMed search [1] [2]

Syntaxin-binding protein 1 is a protein that in humans is encoded by the STXBP1 gene.[1][2]

In melanocytic cells STXBP1 gene expression may be regulated by MITF.[3]


Interactions[edit]

STXBP1 has been shown to interact with STX2,[4][5] STX4[4][5] and STX1A.[5][6][7][8][9]

References[edit]

  1. ^ Swanson DA, Steel JM, Valle D (Jun 1998). "Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release". Genomics 48 (3): 373–6. doi:10.1006/geno.1997.5202. PMID 9545644. 
  2. ^ "Entrez Gene: STXBP1 syntaxin binding protein 1". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  4. ^ a b Schraw, Todd D; Lemons Paula P; Dean William L; Whiteheart Sidney W (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. (England) 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. ISSN 0264-6021. PMC 1223584. PMID 12773094. 
  5. ^ a b c Hata, Y; Südhof T C (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. (UNITED STATES) 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. ISSN 0021-9258. PMID 7768895. 
  6. ^ Bhaskar, Kiran; Shareef Mohammed Momin; Sharma Vandana M; Shetty A Pavan Kumar; Ramamohan Y; Pant Harish C; Raju T R; Shetty K Taranath (Jan 2004). "Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins". Neurochem. Int. (England) 44 (1): 35–44. doi:10.1016/S0197-0186(03)00099-8. ISSN 0197-0186. PMID 12963086. 
  7. ^ Dulubova, I; Sugita S; Hill S; Hosaka M; Fernandez I; Südhof T C; Rizo J (Aug 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". EMBO J. (ENGLAND) 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. ISSN 0261-4189. PMC 1171512. PMID 10449403. 
  8. ^ McMahon, H T; Missler M; Li C; Südhof T C (Oct 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell (UNITED STATES) 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. ISSN 0092-8674. PMID 7553862. 
  9. ^ Pérez-Brangulí, Francesc; Muhaisen Ashraf; Blasi Juan (Jun 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Mol. Cell. Neurosci. (United States) 20 (2): 169–80. doi:10.1006/mcne.2002.1122. ISSN 1044-7431. PMID 12093152. 

Further reading[edit]