SULT1A1

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Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
Protein SULT1A1 PDB 1cjm.png
PDB rendering based on 1cjm.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SULT1A1 ; HAST1/HAST2; P-PST; PST; ST1A1; ST1A3; STP; STP1; TSPST1
External IDs OMIM171150 MGI102896 HomoloGene68152 ChEMBL: 1743291 GeneCards: SULT1A1 Gene
EC number 2.8.2.1
RNA expression pattern
PBB GE SULT1A1 203615 x at tn.png
PBB GE SULT1A1 207122 x at tn.png
PBB GE SULT1A1 209607 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6817 20887
Ensembl ENSG00000196502 ENSMUSG00000030711
UniProt P50225 D3Z2P8
RefSeq (mRNA) NM_001055 NM_133670.1
RefSeq (protein) NP_001046 NP_598431.1
Location (UCSC) Chr 16:
28.62 – 28.63 Mb
Chr 7:
133.82 – 133.82 Mb
PubMed search [1] [2]

Sulfotransferase 1A1 is an enzyme that in humans is encoded by the SULT1A1 gene.[1][2][3]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene.[3]

References[edit]

  1. ^ Dooley TP, Obermoeller RD, Leiter EH, Chapman HD, Falany CN, Deng Z, Siciliano MJ (Feb 1994). "Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7". Genomics 18 (2): 440–3. doi:10.1006/geno.1993.1494. PMID 8288252. 
  2. ^ Dooley TP, Huang Z (Dec 1996). "Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16". Biochem Biophys Res Commun 228 (1): 134–40. doi:10.1006/bbrc.1996.1628. PMID 8912648. 
  3. ^ a b "Entrez Gene: SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1". 

Further reading[edit]