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Small ubiquitin-like modifier 2
Protein SUMO2 PDB 1u4a.png
PDB rendering based on 1u4a.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SUMO2 ; HSMT3; SMT3B; SMT3H2; SUMO3; Smt3A
External IDs OMIM603042 MGI2158813 HomoloGene87858 GeneCards: SUMO2 Gene
Species Human Mouse
Entrez 6613 170930
Ensembl ENSG00000188612 ENSMUSG00000020738
UniProt P61956 P61957
RefSeq (mRNA) NM_001005849 NM_133354
RefSeq (protein) NP_001005849 NP_579932
Location (UCSC) Chr 17:
75.17 – 75.18 Mb
Chr 11:
115.52 – 115.54 Mb
PubMed search [1] [2]

Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene.[1]

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]


SUMO2 has been shown to interact with TRIM63[3] and c21orf59.[4]


  1. ^ Mannen H, Tseng HM, Cho CL, Li SS (June 1996). "Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene". Biochem Biophys Res Commun 222 (1): 178–80. doi:10.1006/bbrc.1996.0717. PMID 8630065. 
  2. ^ "Entrez Gene: SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)". 
  3. ^ Dai, K S; Liew C C (June 2001). "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain". J. Biol. Chem. (United States) 276 (26): 23992–9. doi:10.1074/jbc.M011208200. ISSN 0021-9258. PMID 11283016. 
  4. ^ Golebiowski, F.; Matic, I.; Tatham, M. H.; Cole, C.; Yin, Y.; Nakamura, A.; Cox, J.; Barton, G. J.; Mann, M.; Hay, R. T. (2009). "System-Wide Changes to SUMO Modifications in Response to Heat Shock". Science Signaling 2 (72): ra24. doi:10.1126/scisignal.2000282. PMID 19471022.  edit

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