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Surfeit 4
Symbols SURF4 ; ERV29
External IDs OMIM185660 MGI98445 HomoloGene6052 GeneCards: SURF4 Gene
Species Human Mouse
Entrez 6836 20932
Ensembl ENSG00000148248 ENSMUSG00000014867
UniProt O15260 Q64310
RefSeq (mRNA) NM_001280788 NM_011512
RefSeq (protein) NP_001267717 NP_035642
Location (UCSC) Chr 9:
136.23 – 136.24 Mb
Chr 2:
26.92 – 26.93 Mb
PubMed search [1] [2]

Surfeit locus protein 4 is a protein that in humans is encoded by the SURF4 gene.[1][2][3]

This gene is located in the surfeit gene cluster, which is composed of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). The specific function of this protein has not been determined but its yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles. This gene uses multiple polyadenylation sites, resulting in transcript length variation. The existence of alternatively spliced transcript variants has been suggested, but their validity has not been determined.[3]


  1. ^ Yon J, Jones T, Garson K, Sheer D, Fried M (Jun 1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum Mol Genet 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913. 
  2. ^ Reeves JE, Fried M (Aug 1995). "The surf-4 gene encodes a novel 30 kDa integral membrane protein". Mol Membr Biol 12 (2): 201–8. doi:10.3109/09687689509027508. PMID 7540914. 
  3. ^ a b "Entrez Gene: SURF4 surfeit 4". 

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