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Vesicle-associated membrane protein 7
Protein SYBL1 PDB 2dmw.png
PDB rendering based on 2dmw.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM300053 MGI1096399 HomoloGene4121 GeneCards: VAMP7 Gene
RNA expression pattern
PBB GE SYBL1 202829 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6845 20955
Ensembl ENSG00000124333 ENSMUSG00000051412
UniProt P51809 P70280
RefSeq (mRNA) NM_001145149 NM_011515
RefSeq (protein) NP_001138621 NP_035645
Location (UCSC) Chr X:
155.11 – 155.17 Mb
Chr GL456233.1:
0.01 – 0.04 Mb
PubMed search [1] [2]

Vesicle-associated membrane protein 7 (VAMP-7) is a protein that in humans is encoded by the VAMP7 gene.[1][2][3]


VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. VAMP-7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.[3]


SYBL1 has been shown to interact with SNAP23[4][5] and AP3D1.[4]


  1. ^ D'Esposito M, Ciccodicola A, Gianfrancesco F, Esposito T, Flagiello L, Mazzarella R et al. (Jul 1996). "A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation". Nat. Genet. 13 (2): 227–9. doi:10.1038/ng0696-227. PMID 8640232. 
  2. ^ Filippini F, Rossi V, Galli T, Budillon A, D'Urso M, D'Esposito M (Jul 2001). "Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain". Trends Biochem. Sci. 26 (7): 407–9. doi:10.1016/S0968-0004(01)01861-8. PMID 11440841. 
  3. ^ a b "Entrez Gene: SYBL1 synaptobrevin-like 1". 
  4. ^ a b Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V et al. (Jul 2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575. 
  5. ^ Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M et al. (Jun 1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.