SYN3

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Synapsin III
Protein SYN3 PDB 2p0a.png
PDB rendering based on 2p0a.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol SYN3
External IDs OMIM602705 MGI1351334 HomoloGene68320 GeneCards: SYN3 Gene
RNA expression pattern
PBB GE SYN3 206322 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8224 27204
Ensembl ENSG00000185666 ENSMUSG00000059602
UniProt O14994 Q8JZP2
RefSeq (mRNA) NM_001135774 NM_001164495
RefSeq (protein) NP_001129246 NP_001157967
Location (UCSC) Chr 22:
32.91 – 33.45 Mb
Chr 10:
86.06 – 86.5 Mb
PubMed search [1] [2]

Synapsin-3 is a protein that in humans is encoded by the SYN3 gene.[1][2]

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in six transcript variants; however, only two variants have been fully described.[2]

References[edit]

  1. ^ Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Haring M, Benfenati F, Greengard P (May 1998). "A third member of the synapsin gene family". Proc Natl Acad Sci U S A 95 (8): 4667–72. doi:10.1073/pnas.95.8.4667. PMC 22548. PMID 9539796. 
  2. ^ a b "Entrez Gene: SYN3 synapsin III". 

Further reading[edit]