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Synaptotagmin binding, cytoplasmic RNA interacting protein
Protein SYNCRIP PDB 2dgu.png
PDB rendering based on 2dgu.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs MGI1891690 HomoloGene4648 GeneCards: SYNCRIP Gene
RNA expression pattern
PBB GE SYNCRIP 217833 at tn.png
PBB GE SYNCRIP 209024 s at tn.png
PBB GE SYNCRIP 217832 at tn.png
More reference expression data
Species Human Mouse
Entrez 10492 56403
Ensembl ENSG00000135316 ENSMUSG00000032423
UniProt O60506 Q7TMK9
RefSeq (mRNA) NM_001159673 NM_001284328
RefSeq (protein) NP_001153145 NP_001271257
Location (UCSC) Chr 6:
86.32 – 86.35 Mb
Chr 9:
88.45 – 88.48 Mb
PubMed search [1] [2]

Heterogeneous nuclear ribonucleoprotein Q is a protein that in humans is encoded by the SYNCRIP gene.[1][2][3]


SYNCRIP has been shown to interact with ACF,[2][4] APOBEC1,[2] SYT7[5] and SYT9,[5]


  1. ^ Harris CE, Boden RA, Astell CR (January 1999). "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice". J Virol 73 (1): 72–80. PMC 103810. PMID 9847309. 
  2. ^ a b c Lau PP, Chang BH, Chan L (May 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome". Biochem Biophys Res Commun 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. PMID 11352648. 
  3. ^ "Entrez Gene: SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein". 
  4. ^ Blanc, V; Navaratnam N; Henderson J O; Anant S; Kennedy S; Jarmuz A; Scott J; Davidson N O (March 2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". J. Biol. Chem. (United States) 276 (13): 10272–83. doi:10.1074/jbc.M006435200. ISSN 0021-9258. PMID 11134005. 
  5. ^ a b Mizutani, A; Fukuda M; Ibata K; Shiraishi Y; Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. (UNITED STATES) 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. ISSN 0021-9258. PMID 10734137. 

Further reading[edit]