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Synaptotagmin VI
Symbols SYT6 ; sytVI
External IDs OMIM607718 MGI1859544 HomoloGene10301 GeneCards: SYT6 Gene
Species Human Mouse
Entrez 148281 54524
Ensembl ENSG00000134207 ENSMUSG00000027849
UniProt Q5T7P8 Q9R0N8
RefSeq (mRNA) NM_001253772 NM_001276676
RefSeq (protein) NP_001257734 NP_001263605
Location (UCSC) Chr 1:
114.63 – 114.7 Mb
Chr 3:
103.58 – 103.65 Mb
PubMed search [1] [2]

Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.[1][2]

Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM][2]


  1. ^ Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631. 
  2. ^ a b "Entrez Gene: SYT6 synaptotagmin VI". 

Further reading[edit]

  • Gregory SG; Barlow KF; McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Roggero CM; Tomes CN; De Blas GA et al. (2006). "Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis". Dev. Biol. 285 (2): 422–35. doi:10.1016/j.ydbio.2005.07.007. PMID 16111671. 
  • Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Michaut M; De Blas G; Tomes CN et al. (2001). "Synaptotagmin VI participates in the acrosome reaction of human spermatozoa". Dev. Biol. 235 (2): 521–9. doi:10.1006/dbio.2001.0316. PMID 11437455. 
  • Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523. 
  • Li C; Ullrich B; Zhang JZ et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.