SYTL1

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Synaptotagmin-like 1
Identifiers
Symbols SYTL1 ; JFC1; SLP1
External IDs OMIM608042 MGI1933365 HomoloGene12853 GeneCards: SYTL1 Gene
Orthologs
Species Human Mouse
Entrez 84958 269589
Ensembl ENSG00000142765 ENSMUSG00000028860
UniProt Q8IYJ3 A2AE94
RefSeq (mRNA) NM_001193308 NM_031393
RefSeq (protein) NP_001180237 NP_113570
Location (UCSC) Chr 1:
27.67 – 27.68 Mb
Chr 4:
133.25 – 133.26 Mb
PubMed search [1] [2]

Synaptotagmin-like protein 1 is a protein that in humans is encoded by the SYTL1 gene.[1][2]


Model organisms[edit]

Model organisms have been used in the study of SYTL1 function. A conditional knockout mouse line, called Sytl1tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty four tests were carried out on homozygous mutant mice and six significant abnormalities were observed.[9] Females had abnormal locomotor coordination, caudal vertebral transformation, decreased circulating amylase levels and increased mean platelet volume. Both sexes displayed decreased IgG2b levels and abnormal peripheral blood lymphocyte parameters.[9]

Interactions[edit]

SYTL1 has been shown to interact with RAB27A.[17][18][19]

References[edit]

  1. ^ Catz SD, Babior BM, Johnson JL (Oct 2002). "JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells". Biochem J 367 (Pt 3): 791–9. doi:10.1042/BJ20020345. PMC 1222920. PMID 12137562. 
  2. ^ "Entrez Gene: SYTL1 synaptotagmin-like 1". 
  3. ^ "Radiography data for Sytl1". Wellcome Trust Sanger Institute. 
  4. ^ "Clinical chemistry data for Sytl1". Wellcome Trust Sanger Institute. 
  5. ^ "Haematology data for Sytl1". Wellcome Trust Sanger Institute. 
  6. ^ "Peripheral blood lymphocytes data for Sytl1". Wellcome Trust Sanger Institute. 
  7. ^ "Salmonella infection data for Sytl1". Wellcome Trust Sanger Institute. 
  8. ^ "Citrobacter infection data for Sytl1". Wellcome Trust Sanger Institute. 
  9. ^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  10. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ^ "International Knockout Mouse Consortium". 
  12. ^ "Mouse Genome Informatics". 
  13. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  14. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  15. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  16. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 
  17. ^ Fukuda, Mitsunori (Apr 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. (United States) 278 (17): 15390–6. doi:10.1074/jbc.M213090200. ISSN 0021-9258. PMID 12590134. 
  18. ^ Strom, Molly; Hume Alistair N, Tarafder Abul K, Barkagianni Eleni, Seabra Miguel C (Jul 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". J. Biol. Chem. (United States) 277 (28): 25423–30. doi:10.1074/jbc.M202574200. ISSN 0021-9258. PMID 11980908. 
  19. ^ Kuroda, Taruho S; Fukuda Mitsunori, Ariga Hiroyoshi, Mikoshiba Katsuhiko (Mar 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. (United States) 277 (11): 9212–8. doi:10.1074/jbc.M112414200. ISSN 0021-9258. PMID 11773082. 

Further reading[edit]