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Synaptotagmin-like 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SYTL2 ; CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2; SLP2A
External IDs OMIM612880 MGI1933366 HomoloGene131343 GeneCards: SYTL2 Gene
RNA expression pattern
PBB GE SYTL2 220613 s at tn.png
More reference expression data
Species Human Mouse
Entrez 54843 83671
Ensembl ENSG00000137501 ENSMUSG00000030616
UniProt Q9HCH5 Q99N50
RefSeq (mRNA) NM_001162951 NM_001040085
RefSeq (protein) NP_001156423 NP_001035174
Location (UCSC) Chr 11:
85.41 – 85.52 Mb
Chr 7:
90.35 – 90.41 Mb
PubMed search [1] [2]

Synaptotagmin-like 2, also known as SYTL2, is a human gene.[1]

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.[1]


SYTL2 has been shown to interact with RAB27A.[2][3][4]


  1. ^ a b "Entrez Gene: SYTL2 synaptotagmin-like 2". 
  2. ^ Fukuda, Mitsunori (Apr 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. (United States) 278 (17): 15390–6. doi:10.1074/jbc.M213090200. ISSN 0021-9258. PMID 12590134. 
  3. ^ Strom, Molly; Hume Alistair N; Tarafder Abul K; Barkagianni Eleni; Seabra Miguel C (Jul 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". J. Biol. Chem. (United States) 277 (28): 25423–30. doi:10.1074/jbc.M202574200. ISSN 0021-9258. PMID 11980908. 
  4. ^ Kuroda, Taruho S; Fukuda Mitsunori; Ariga Hiroyoshi; Mikoshiba Katsuhiko (Mar 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. (United States) 277 (11): 9212–8. doi:10.1074/jbc.M112414200. ISSN 0021-9258. PMID 11773082. 

Further reading[edit]