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Synovial apoptosis inhibitor 1, synoviolin
Symbols SYVN1 ; DER3; HRD1
External IDs OMIM608046 MGI1921376 HomoloGene32700 GeneCards: SYVN1 Gene
EC number 6.3.2.-
Species Human Mouse
Entrez 84447 74126
Ensembl ENSG00000162298 ENSMUSG00000024807
UniProt Q86TM6 Q9DBY1
RefSeq (mRNA) NM_032431 NM_001164709
RefSeq (protein) NP_115807 NP_001158181
Location (UCSC) Chr 11:
64.89 – 64.9 Mb
Chr 19:
6.05 – 6.05 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase synoviolin is an enzyme that in humans is encoded by the SYVN1 gene.[1][2]

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence. Sequence analysis identified two transcript variants that encode different isoforms.[2]


  1. ^ Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zhang L, Ikeda R, Fujii R, Miura N, Komiya S, Nishioka K, Maruyama I, Fukamizu A, Nakajima T (Oct 2003). "Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy". Genes Dev 17 (19): 2436–49. doi:10.1101/gad.1096603. PMC 218080. PMID 12975321. 
  2. ^ a b "Entrez Gene: SYVN1 synovial apoptosis inhibitor 1, synoviolin". 

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