Sabeluzole

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Sabeluzole
Sabeluzole structure.png
Systematic (IUPAC) name
1-[4-[1,3-benzothiazol-2-yl(methyl)amino]piperidin-1-yl]-3-(4-fluorophenoxy)propan-2-ol
Clinical data
Legal status Unscheduled
Identifiers
CAS number 104383-17-7
ATC code None
PubChem CID 59823
ChemSpider 53964
UNII A998504XY4 YesY
Chemical data
Formula C22H26FN3O2S 
Mol. mass 415.524 g/mol
 YesY (what is this?)  (verify)

Sabeluzole (R-58,735) is a nootropic and neuroprotective drug which was originally developed for the treatment of Alzheimer's disease,[1][2] and has subsequently been researched for other applications such as sleep apnoea.[3] It acts primarily as an NMDA antagonist,[4] but other mechanisms of action may also be important.[5][6]


See also[edit]

References[edit]

  1. ^ Clincke GH, Tritsmans L, Idzikowski C, Amery WK, Janssen PA (1988). "The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers". Psychopharmacology 94 (1): 52–7. doi:10.1007/BF00735880. PMID 3126527. 
  2. ^ Mohr E, Nair NP, Sampson M, Murtha S, Belanger G, Pappas B, Mendis T (August 1997). "Treatment of Alzheimer's disease with sabeluzole: functional and structural correlates". Clinical Neuropharmacology 20 (4): 338–45. PMID 9260731. 
  3. ^ Hedner J, Grunstein R, Eriksson B, Ejnell H (May 1996). "A double-blind, randomized trial of sabeluzole--a putative glutamate antagonist--in obstructive sleep apnea". Sleep 19 (4): 287–9. PMID 8776785. 
  4. ^ Van der Valk JB, Vijverberg HP (February 1993). "Chronic sabeluzole treatment of cultured rat cerebellar granule cells reduces N-methyl-D-aspartate-induced inward current". European Journal of Pharmacology 232 (1): 131–4. doi:10.1016/0014-2999(93)90738-4. PMID 8458392. 
  5. ^ Geerts H, Nuydens R, De Jong M, Cornelissen F, Nuyens R, Wouters L (1996). "Sabeluzole stabilizes the neuronal cytoskeleton". Neurobiology of Aging 17 (4): 573–81. PMID 8832632. 
  6. ^ Uberti D, Rizzini C, Galli P, Pizzi M, Grilli M, Lesage A, Spano P, Memo M (June 1997). "Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death". Synapse (New York, N.Y.) 26 (2): 95–103. doi:10.1002/(SICI)1098-2396(199706)26:2<95::AID-SYN1>3.0.CO;2-8. PMID 9131769.