Saco is an unincorporated community in Twelvemile Township in southern Madison County, Missouri, United States. It is located about sixteen miles southwest of Fredericktown on Missouri Supplemental Route C. It was founded by John DeSpain before 1850. The name Saco was given by Carrol Ally when the post office was applied for in 1890. The name is said to be coined, but the original words from which the syllables were selected are unknown.
Coordinates: 37°21′56″N 90°26′21″W / 37.36556°N 90.43917°W