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It was set up as a Benedictine community, whose monks cared for the shrine and the relics, while the Brothers cared for those suffering from the then common malady of St. Anthony's Fire. Over the course of the next two centuries, disputes between the Antonines and the Benedictines arose repeatedly. Finally, the Antonines were formed into an Order of canons regular in 1297. At that time the Benedictine monks were removed from the shrine, which was entrusted to the Antonines.