The Salisbury Mansion and Store is a historic house museum at 40 Highland Street in Worcester, Massachusetts. The house was built in 1772 by Stephen Salisbury with an attached storehouse from which he sold imported goods. In 1820 the store was closed down, and the space was converted for residential use by the family, which occupied it until 1851. Thereafter it served as a girl's school, tenant house, and then a gentleman's social club until 1929, when the building was donated to the American Antiquarian Society, which promptly gave it to the Worcester Art Museum. The museum moved the house to its present location to make way for Worcester Memorial Auditorium in 1929. It was leased to a nonprofit, and eventually acquired by the Worcester Historic Museum in 1985. The museum undertook to restore the much-altered building to its condition as of 1830, and opened it as a museum.