Salivary gland
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| Salivary gland | |
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| Salivary glands: #1 is Parotid gland, #2 is Submandibular gland, #3 is Sublingual gland | |
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| Salivary+Glands | |
| Latin | glandulae salivariae |
The salivary glands in mammals are exocrine glands, glands with ducts, that produce saliva. They also secrete amylase, an enzyme that breaks down starch into glucose. In other organisms such as insects, salivary glands are often used to produce biologically important proteins like silk or glues, and fly salivary glands contain polytene chromosomes that have been useful in genetic research.
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[edit] Histology
The glands are enclosed in a capsule of connective tissue and internally divided into lobules. Blood vessels and nerves enter the glands at the hilum and gradually branch out into the lobules.
[edit] Ducts
In the duct system, the lumens formed by intercalated ducts, which in turn join to form striated ducts. These drain into ducts situated between the lobes of the gland (called interlobar ducts or secretory ducts).
All of the human salivary glands terminate in the mouth, where the saliva proceeds to aid in digestion. The saliva that salivary glands release is quickly inactivated in the stomach by the acid that is present there.
[edit] Anatomy
[edit] Parotid Glands
The parotid glands are a pair of glands located in the subcutaneous tissues of the face overlying the mandibular ramus and anterior and inferior to the external ear. The secretion produced by the parotid glands is serous in nature, and enters the oral cavity through the Stensen's duct after passing through the intercalated ducts which are prominent in the gland. Despite being the largest pair of glands, only approximately 25% of saliva is produced by the glands.Saliva contains a mixture of enzymes like salivary amylase (ptyalin), maltase(trace amounts), lysozyme (which disinfect and kills bacteria and germs which enter the mouth), salts and water. Saliva helps converting starch into maltose which is then converted patially to glucose by the maltase.
[edit] Submandibular Glands
The submandibular glands are a pair of glands located beneath lower jaws, superior to the digastric muscles. The secretion produced is a mixture of both serous and mucous and enters the oral cavity via Wharton's ducts. Approximately 70% of saliva in the oral cavity is produced by the submandibular glands, even though they are much smaller than the parotid glands.
[edit] Sublingual Gland
The sublingual glands are a pair of glands located beneath the tongue to the submandibular glands. The secretion produced is mainly mucous in nature, however it is categorized as a mixed gland. Unlike the other two major glands, the ductal system of the sublingual glands do not have striated ducts, and exit from 8-20 excretory ducts. Approximately 5% of saliva entering the oral cavity come from these glands.
[edit] Minor Salivary Glands
There are over 600 minor salivary glands located throughout the oral cavity within the lamina propria of the oral mucosa. They are 1-2mm in diameter and unlike the other glands, they are not encapsulated by connective tissue only surrounded by it. The gland is usually a number of acini connected in a tiny lobule. A minor salivary gland may have a common excretory duct with another gland, or may have its own excretory duct. Their secretion is mainly mucous in nature (except for Von Ebner's glands) and have many functions such as coating the oral cavity with saliva. Problems with dentures are usually associated with minor salivary glands.[1]
[edit] Von Ebner's Glands
Von Ebner's glands are glands found in circumvallate papillae of the tongue. They secrete a serous fluid that begin lipid hydrolysis. They are an essential component of taste.
[edit] Innervation
Salivary glands are innervated, either directly or indirectly, by the parasympathetic and sympathetic arms of the autonomic nervous system.
- Parasympathetic innervation to the salivary glands is carried via cranial nerves. The parotid gland receives its parasympathetic input from the glossopharyngeal nerve (CN IX) via the otic ganglion, while the submandibular and sublingual glands receive their parasympathetic input from the facial nerve (CN VII) via the submandibular ganglion.
- Direct sympathetic innervation of the salivary glands takes place via preganglionic nerves in the thoracic segments T1-T3 which synapse in the superior cervical ganglion with postganglionic neurons that release norepinephrine, which is then received by β-adrenergic receptors on the acinar and ductal cells of the salivary glands, leading to an increase in cyclic adenosine monophosphate (cAMP) levels and the corresponding increase of saliva secretion. Note that in this regard both parasympathetic and sympathetic stimuli result in an increase in salivary gland secretions.[2] The sympathetic nervous system also affects salivary gland secretions indirectly by innervating the blood vessels that supply the glands.
[edit] Role in disease
- See mumps (parotiditis epidemica), Sjögren's syndrome, Mucocele, and Salivary gland neoplasm.
Salivary duct calculus may cause blockage of the ducts, causing pain and swelling of the gland.
Tumors of the salivary glands may occur.
[edit] Iodine in salivary glands and oral health
[edit] Diagnostic investigation
A sialogram is a radiocontrast study of a salivary duct.
[edit] In other animals
In most vertebrates, saliva does not contain any enzymes, consisting of mucus and water only, and its primary function is to moisten food while eating. As a result, true salivary glands are rarely found in fish or aquatic tetrapods, although there are often individual mucus-secreting cells. Amphibians have a single salivary gland, the intermaxillary gland, located in the forward part of the palate. Reptiles and birds normally have only very small glands on the lips, palate, and base of the mouth, although there are some birds with large glands, which produce a sticky saliva that helps in nest-building. The distinct parotid, submandibular, and sublingual glands are only developed in mammals.[3]
The salivary glands of some species, however, are modified to produce enzymes; salivary amylase is found in many, but by no means all, bird and mammal species (including humans, as noted above). Furthermore, the venom glands of poisonous snakes, gila monsters, and some shrews, are modified salivary glands.[3]
[edit] See also
[edit] References
- ^ Cate, A.R. Ten. hi dude Oral Histology: development, structure, and function. 5th ed. 1998. Page 3. ISBN 0-8151-2952-1.
- ^ Costanzo, L. (2006). Physiology, 3rd ed.. Saunders Elsevier. ISBN 10:1-4160-2320-8.
- ^ a b Romer, Alfred Sherwood; Parsons, Thomas S. (1977). The Vertebrate Body. Philadelphia, PA: Holt-Saunders International. pp. 299-300. ISBN 0-03-910284-X.
- Venturi S, Venturi M. (2009). Iodine in evolution of salivary glands and in oral health. Nutrition and Health. 20 :119–134. PMID: 19835108
- Bahar, G., Feinmesser, R., Shpitzer, T., Popovtzer, A. and Nagler, R.M. (2007). Salivary analysis in oral cancer patients: DNA and protein oxidation, reactive nitrogen species, and antioxidant profile. Cancer, 109, 54–9.
- Banerjee, R.K., Bose, A.K., Chakraborty, T.K., de, S.K. and Datta, A.G. (1985). Peroxidase-catalysed iodotyrosine formation in dispersed cells of mouse extrathyroidal tissues. J Endocrinol. 2, 159–65.
- Banerjee, R.K. and datta, A.G. (1986). Salivary peroxidases. Mol Cell Biochem, 70, 21-9.
- Bartelstone, H. J. (1951). Radioiodine penetration through intact enamel with uptake by bloodstream and thyroid gland. J Dent Res. 5 :728–33.
- Bartelstone, H.J., Mandel, I.D., Oshry, E. and Seidlin, S.M. (1947). Use of radioactive iodine as a tracer in the Study of the Physiology of teeth. Science. 106, 132.
[edit] External links
- Salivary Gland Disorders at intelihealth.com
- Illustration at merck.com
- Illustration at .washington.edu
- Photo at mgccc.cc.ms.us
- plastic/371 at eMedicine - "Parotid Tumors, Benign"
- Parotid Gland Removal
- Submandibular Gland Removal
- Sublingual Gland Removal
- Medical Encyclopedia Medline Plus: Salivary gland
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