Acetaminosalol

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Acetaminosalol
Kekulé, skeletal formula of acetaminosalol
Identifiers
CAS number 118-57-0 N
PubChem 1984
ChemSpider 1907 YesY
EC number 204-261-3
MeSH Salophen
ChEBI CHEBI:250620 N
ChEMBL CHEMBL92590 YesY
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C15H13NO4
Molar mass 271.27 g mol−1
Density 1.327 g cm-3
log P 2.562
Acidity (pKa) 7.874
Basicity (pKb) 6.123
Hazards
Flash point 241.9 °C (467.4 °F; 515.0 K)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Acetaminosalol is an organic compound with the chemical formula C15H13NO4.

It is an esterfication product of salicylic acid and paracetamol. It was marketed by Bayer under the brand name Salophen as an analgesic in the late 19th and early 20th centuries.

Action and uses[edit]

In a warm alkaline solution acetaminosalol is broken up into salicylic acid and paracetamol. It is decomposed in the intestines, even when given as an injection. It was used as a substitute for salicylic acid in acute rheumatism, and as an intestinal antiseptic. It was similarly effective and much safer than salol, another intestinal antiseptic commonly used at the time. The fact that it is tasteless renders it easy to administer.

Advertisement for early 20th century Bayer products, including Salophen

References[edit]

  1. ^ "salophen - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology Information.