Egwu was former President Olusegun Obasanjo's choice to become National Chairman of the PDP at its 2008 National Convention. However, at the Convention on March 8, 2008, he withdrew in favor of the compromise candidate Prince Vincent Ogbulafor, who was chosen as an alternative to Egwu and his main rival for the position, Anyim Pius Anyim. His stay as education minister was characterized by ASUU (Academic Staff Union of Universities) and other university union strikes. This led to people demanding for his sack.
The Cabinet of President Umaru Yar'Adua, which was formed on 26 July 2007, is shown below. The list shows Federal Ministers but excludes Ministers of State, who assist the Federal Ministers. The cabinet was dissolved on 17 March 2010 by Acting President Goodluck Jonathan, and a new cabinet sworn in in 6 April 2010.