Born in Blandford, Massachusetts, Knox attended the common schools. He graduated from Williams College, Williamstown, Massachusetts, in 1836 and from the law department of Harvard University in 1838. He moved to St. Louis, Missouri, in 1838. He was admitted to the bar and practiced law there, then became city counselor in 1845. He successfully opposed Francis P. Blair, Jr. as an Unconditional Unionist in the election to the Thirty-eighth Congress and served from June 10, 1864, to March 3, 1865. He was unsuccessful for reelection in 1864 to the Thirty-ninth Congress. He resumed the practice of law in St. Louis, Missouri. He returned to Blandford, Massachusetts, where he died March 7, 1905. He was interred in Peabody Cemetery, Springfield, Massachusetts. Samuel Knox provided the land for the Alpine Community Church.
|United States House of Representatives|
Francis Preston Blair, Jr.
|Member of the U.S. House of Representatives
from Missouri's 1st congressional district