Woodhouse was doctor and naturalist on the Sitgreaves Expedition led by Captain Lorenzo Sitgreaves from San Antonio to San Diego which explored the possibility of a route from the Zuni River to the Pacific. He was the author of A Naturalist in Indian Territory: The Journal of S. W. Woodhouse, 1849-50. The Woodhouse's Toad (Bufo woodhousii) was named in his honor.
Woodhouse, S.W., edited and annotated by Andrew Wallace and Richard H. Hevly, From Texas to San Diego in 1851: The Overland Journal of Dr. S.W. Woodhouse, Surgeon-Naturalist of the Sitgreaves Expedition, Texas Tech University Press (2007), hardcover, 358 pages, ISBN 578-0-89672-597-3
The original is a manuscript in the manuscript collections of the Academy of Natural Sciences of Philadelphia, Diary of an Expedition Down the Zuni and Colorado Rivers under Captain L. Sitgreaves 1851-52, 4 volumes, item 387B