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San Xavier may refer to:
- Francis Xavier (1506–1552), Roman Catholic missionary
- San Javier, Ñuflo de Chávez, Santa Cruz Department, Bolivia
- San Xavier Indian Reservation, near Tucson, Arizona, United States
- Mission San Xavier del Bac, a historic Spanish Catholic mission on San Xavier Indian Reservation
- San Xavier, Arizona, a small mining town near San Xavier Mission
- San Xavier talus snail (Sonorella eremita), a species of air-breathing land snail
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