Brondello started her WNBA career in 1998 by being selected in the fourth round (34th overall) by the Detroit Shock, becoming an All-Star in the first WNBA All-Star Game in 1999. She was selected by the Indiana Fever in late 1999's expansion draft, but never played a game for them, being traded to the Miami Sol along with a first-round pick for Stephanie McCarty. She signed as a free agent with the Seattle Storm in 2003, joining fellow Opals Lauren Jackson and Tully Bevilaqua. Brondello was one of the top three-point shooters in league history, her .410 percentage ranking fourth all-time.
Brondello chose not to play in the WNBA in 2004 because of a commitment to the Australian Olympic basketball team, which finished with a silver medal for the second time. This was the last major event in which she played.
Brondello and her husband, associate head coach Olaf Lange, were fired by the Silver Stars in September 2010. Brondello finished her only season as head coach with a 14-20 record, third best in the Western Conference. They were eliminated in the first round of the playoffs by Phoenix two games to none. General manager Dan Hughes regained the title of head coach in January 2011, returning to the dual role he held before promoting Brondello.