Sanjiv Sam Gambhir
|Sanjiv Sam Gambhir|
November 23, 1961 |
|Fields||Nuclear Medicine, Radiology, and Bioengineering|
|Alma mater||University of California, Los Angeles|
|Academic advisors||M.E. Phelps, S.C. Huang, and H.R. Herschman|
|Known for||Molecular Imaging, Nuclear Medicine, and PET-CT|
|Notable awards||Institute of Medicine (IOM) of the US National Academies (2008)|
Sanjiv Sam Gambhir, MD, PhD (born November 23, 1962) is an American physician-scientist. He is the Virginia and D.K. Ludwig Professor in Cancer Research, Chairman of the Department of Radiology at Stanford University School of Medicine, and a professor by courtesy in the departments of Bioengineering and Materials Science and Engineering at Stanford University. Additionally, he serves as the Director of the Molecular Imaging Program at Stanford (MIPS) and Canary Center at Stanford for Cancer Early Detection. To date, he serves on many editorial and advisory boards and committees. He serves as the PI to various extramural funds as well as private foundations funds.
Gambhir was born in Ambala, India and moved to the US with his parents and sister in 1969. He was raised in Phoenix, Arizona. He is married to Aruna Bodapati Gambhir, has one son and lives in the Bay Area.
Education and employment
Gambhir is a Phi Beta Kappa graduate of Arizona State University where he received his B.S. in Physics. He then entered the combined M.D-Ph.D. Medical Scientist Training Program (MSTP) at the University of California Los Angeles and received his MD and PhD in biomathematics. He received the highest honor given to a UCLA graduate student, the outstanding graduate student award gold medal award in 1990.
His first academic appointment was in 1994 at UCLA as an Assistant Professor of Molecular & Medical Pharmacology. He was a Clinical Attending in the Nuclear Medicine Department at Center for Health Sciences at UCLA starting in 1997. He was appointed tenure Professorship at UCLA in 2003. In 2003, he moved to Stanford University and was appointed Professor of Radiology, Head of Nuclear Medicine, Director of Molecular Imaging Program at Stanford (MIPS), and Member of the Bio-X Program. He became the Virginia and D.K. Ludwig Professor for Clinical Investigation in Cancer Research, which is an Endowed Professorship in 2009.
Honors and awards
Gambhir has many honors and awards. In the last decade he has received the following: Taplin Award, Holst Medal, Academy of Molecular Imaging (AMI) Distinguished Basic Scientist of the Year Award, Society for Molecular Imaging (SMI) Achievement Award, Distinguished Clinical Scientist Award from Doris Duke Charitable Foundation, Hounsfield Medal (Imperial College London), fellowship of the American Institute for Medical and Biological Engineering (AIMBE)], Paul C. Aebersold Award, Organizer and Co-Chair for the Nobel Symposium in Imaging (2008), Inducted as a member of the American Society of Clinical Investigator (ASCI), Tesla Medal, Elected to the Institute of Medicine (IOM) of the US National Academies, Parmley Prize, Radiological Society of North American (RNSA) Outstanding Researcher Award, The Gopal Subramanian Lifetime Achievement Award, the George Charles de Hevesy Nuclear Pioneer Award, Aunt Minnie Award, Distinguished Scientist Award for Distinguished Contributions to Nuclear Medicine, Society of Asian American Scientists in Cancer Research Award, and the American Association of Indian Scientists in Cancer Research Lifetime Achievement Award. 
His research focuses on imaging assays to monitor fundamental cellular/molecular events in living subjects with an emphasis on cancer. Technologies being utilized include micro-positron emission tomography (microPET), bioluminescence imaging, fluorescence optical imaging, Raman optical imaging, ultrasound, and photoacoustics in small animal models. Particular interest of his research and lab is early cancer detection including combining in vivo and in vitro diagnostics.
Clinical applications in humans include the use of PET-CT with novel tracers and translational trials with new imaging modalities (e.g., Raman and Photoacoustics), strategies for early cancer detection.
Decision Management Models for the use of FDG PET in cancer, PET reporter gene technology, multimodality reporter genes, imaging of gene/cell therapies, imaging of intracellular events in living subjects (e.g., protein-protein interactions), bioluminescence resonance energy transfer (BRET) in living subjects, nanoparticle based imaging, Raman imaging in vivo and photoacoustic imaging with novel imaging agents.
Gambhir has published over 515 publications in peer reviewed journals, has authored and co-authored several textbooks and holds 46 patents that are issued or filed.
- Chan, C.T.; R.E. Reeves, R. Geller, S.S. Yaghoubi, A. Hoehne, D.E. Solow-Cordero, G. Chiosis, T.F. Massoud, R. Paulmurugan, S.S. Gambhir (2012). "Discovery and Validation of Small-Molecule Heat-Shock Protein 90 Inhibitors Through Multimodality Molecular Imaging in Living Subjects.". PNAS USA 109 (37): E2476–85. doi:10.1073/pnas.1205459109. PMC 3443147. PMID 22895790.
- Zavaleta, C.; E. Garai, J.T., Liu, S. Sensam, M.J. Mandella, D. Van de Sompel, S. Friedland, J. Van Dam, C.H. Contag, S.S. Gambhir (2013). "A Raman-Based Endoscopic Strategy for Multiplexed Molecular Imaging.". PNAS USA 110 (25): E2288–97. doi:10.1073/pnas.1211309110. PMC 3690865. PMID 23703909.
- Bohndiek, S.E.; A. Wagadarikar, C.L. Zavaleta, D. Van de Sompel, E. Garai, J.V. Jokerst, S. Yazdanfar, S.S. Gambhir (2013). "A Small Animal Raman Instrument for Rapid, Wide-Area, Spectroscopic Imaging.". PNAS USA 110 (30): 12408–13. doi:10.1073/pnas.1301379110. PMC 3725059. PMID 23821752.
- Ziv, K.; S.S. Gambhir (2013). "Bioengineering and Regenerative Medicine: Keeping Track.". Nature Materials 12 (3): 180–1. doi:10.1038/nmat3579. PMID 23422714.
- Pu, K.; A.J. Shuhendler, J.V. Jokerst, J. Mei. S.S. Gambhir, Z. Bao, J. Rao (2014). "Semiconducting Polymer Nanoparticles as Photoacoustic Molecular Imaging Probes in Living Mice.". Nature Nanotechnology 9 (3): 233–9. doi:10.1038/nnano.2013.302. PMID 24463363.
- Smith, B.R.; E.E.B Ghosn, H. Rallapalli, J.A. Prescher, T. Larson, L.A. Herzenberg, S.S. Gambhir (2014). "Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumor delivery.". Nature Nanotechnology. In-Press.
- Keren, S.; C. Zavaleta, Z., cheng, A. de la Zerda, O. Gheysens, S.S. Gambhir (April 2008). "Non-invasive Molecular Imaging of Small Living Subjects Using Raman Spectroscopy.". PNAS 105 (15): 5844–49. doi:10.1073/pnas.0710575105. PMC 2299220. PMID 18378895.
- Shipper, M.; N. Nakayama-Ratchford, C. Davis, N. Kam, P. Chu, Z. Liu, X. Sun, J. Dai, S.S. Gambhir (April 2008). "A Pilot Toxicology Study of Single-Walled Carbon Nanotubes in a Small Sample of Mice.". Nature Nanotechnology 3 (4): 216–21. doi:10.1038/nnano.2008.68.
- Willmann, J.; N. van Bruggen, L. Dinkelborg, S.S. Gambhir (July 2008). "Molecular Imaging in Drug Development. Nature Reviews Drug Discovery, 7: 591-607, July 2008. (Cover article.)". Nature Reviews Drug Discovery 7 (7): 591–607. doi:10.1038/nrd2290.
- De la Zerda, A.; C. Zavaleta, S. Keren, S. Vaithilingam, S. bodapati, Z. Liu, J. Levi, B. Smith, T. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. Khuri-Yakub, S.S. Gambhir (August 2008). "Carbon Nanotubes as Photoacoustic Molecular Imaging Agents in Living Mice.". Nature Nanotechnology 3 (8): 557–62. doi:10.1038/nnano.2008.231. PMC 2562547. PMID 18772918.
- Yaghoubi, S.; M. Jensen, N. Sastyamurthy, S. Pubhiraja, D. Paid, J. Czernin, S.S. Gambhir (January 2009). "Non-invasive Detection of Therapeutic Cytolytic T-Cells with [18F]-FHBG PET in a Patient with Glioma.". Nature Clinical Practice Oncology 6 (1): 53–8. doi:10.1038/ncponc1278. PMC 3526373. PMID 19015650.
- Zavaleta, C.; B. Smith, I. Wilton, W. Doering, G. Davis, B. Shojaei, M. Natan, S.S. Gambhir (August 2009). "Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy.". PNAS 106 (32): 13511–6. doi:10.1073/pnas.0813327106. PMC 2726370. PMID 19666578.
- D'Souza, A.; J. Tseng, K. Pauly, S. Guccione, J. Rosenberg, S.S. Gambhir, G. Glazer (September 2009). "A Strategy for Blood Biomarker Amplification and Localization using Ultrasound.". PNAS 104 (40): 17152–7. doi:10.1073/pnas.0903437106. PMC 2749842. PMID 19805109.
- Gaster, R.; D. Hall, C. Nielsen, S. Osterfeld, H. Yu, K. Mach, R. Wilson, B. Murmann, J. Liao, S.S. Gambhir*, S. Wang* (August 2010). "Matrix-insensitive Protein Assays Push the Limits of Biosensors in Medicine.". Nature Medicine 15 (11): 1327–32. doi:10.1038/nm.2032. PMID 19820717.
- Massoud, T.; R. Paulmurugan, S.S. Gambhir (August 2010). "A Molecularly Engineered Split Reporter for Imaging Protein Protein Interactions with Positron Emission Tomography.". Nature Medicine 16 (8): 921–6. doi:10.1038/nm.2185. PMC 2917476. PMID 20639890.
- Fan-Minogue, H.; Z. Cao, R. Paulmurugan, C.T. Chan, T.F. Massoud, D.W. Felsher, S.S. Gambhir (September 2010). "Noninvasive Molecular Imaging of c-Myc Activation in Living Mice.". PNAS 107 (36): 15892–7. doi:10.1073/pnas.1007443107. PMC 2936612. PMID 20713710.
- Thakor, A.; R. Luong, R. Paulmurugan, F. Lin, P. Kempen, C. Zavaleta, P. Chu, T.F. Massoud, R. Sinclair, S.S. Gambhir (April 2011). "The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice. (Cover Article)". Science Translational Medicine 3 (79): 79ra33. doi:10.1126/scitranslmed.3001963. PMC 3873137. PMID 21508310.
- Dragulescu-Andrasi, A.; C.T. Chan, A. De, T.F. Massoud, S.S. Gambhir (July 2011). "Bioluminescence Resonance Energy Transfer (BRET) Imaging of Protein-Protein Interactions within Deep Tissues of Living Subjects.". PNAS 108 (20): 12060–5. doi:10.1073/pnas.1100923108. PMC 3141927. PMID 21730157.
- Hori, S.S.; S.S. Gambhir (November 2011). "Mathematical Model Identifies Blood Biomarker-Based Early Cancer Detection Strategies and Limitations.". Science Translational Medicine 3 (109): 109ra116. doi:10.1126/scitranslmed.3003110. PMC 3423335. PMID 22089452.
- Kircher, M.F.; A. de la Zerda, J.V. Jokerst, C.L. Zavaleta, P.J. Kempson, E. Mittra, R. Huang, C. Campos, F. Habte, R. Sinclair, C.W., Brennan, I.K. Mellinghoff, E.C. Holland, S.S. Gambhir (April 2012). "A Brain Tumor Molecular Imaging Strategy Using a New Triple-Modality MRI-Photoacoustic-Raman Nanoparticle.". Nature Medicine 18 (5): 829–34. doi:10.1038/nm.2721. PMC 3422133. PMID 22504484.
- Jokerst, J.; C. Khademi, S.S. Gambhir (2013). "Intracellular Aggregation of Multimodal Silica Nanoparticles for Ultrasound-Guided Stem Cell Implantation.". Science Translational Medicine 5 (177): 177ra35. doi:10.1126/scitranslmed.3005228. PMC 3839309. PMID 23515077.
- Loening, A. Dragulescu-Andrasi, S.S. Gambhir. (2010). "A Red-Shifted Renilla Luciferase for Transient Reporter-Gene Expression.". Nature Methods 7 (1): 5–6. doi:10.1038/nmeth0110-05. PMID 20038949.
- "Endowed professorships for Gambhir and Relman". Stanford Report. June 2009. Retrieved 2 January 2013.
- May 9, 2011 - The Dean's Newsletter - Stanford University School of Medicine
- Medical Center People
- 2004 News - MIPS: Molecular Imaging Program at Stanford - Stanford Medicine
- Gambhir Receives SMI’s Achievement Award
- Doctors win $1.5 million awards for cancer research
- Medical Center People
- College of Fellows : AIMBE
- Aebersold Award Presented to Gambhir
- ASCI - The American Society for Clinical Investigation
- Sanjiv Gambhir - Institute of Medicine
- 2009 RSNA Outstanding Researcher,
- IASNM-News & Awards
- Sanjiv Sam Gambhir, MD, PhD, Receives SNM’s 2011 Georg Charles de Hevesy Nuclear Pioneer Award