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Santee may refer to:
- Santee people, a subgroup of the Dakota people, a plains tribe
- Santee tribe, an Indian tribe recognized by the state of South Carolina
- Santee, California
- Santee, Nebraska
- Santee, South Carolina
- Santee Indian Reservation in Nebraska
- Santee River in South Carolina
- Lake Santee, Indiana, a reservoir and census-designated place
- Santee, plumbing fitting: a portmanteau of "sanitation" and "tee," referring to a tee joint in a sanitation line
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