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Santhanam or Santanam (Telugu: సంతానం) is an Indian name that may refer to:
- K. Santhanam (1895–1980), Tamil Nadu politician
- Madabusi Santanam Raghunathan (born 1941), Indian mathematician
- Maharajapuram Santhanam (1928–1992), Carnatic music vocalist
- N. Santhanam (born 1980), Tamil comedian and film actor
- Srini Santhanam (born 1984), Indian-American cricketer
- Vaidhyanathaswamy Santhanam (born 1925), Indian cotton scientist
- Santhanam (film), a 1955 Telugu film
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