As of 2005, Santiago Tilantongo had a total population of 3348 living in 827 residences. Almost half speak an indigenous language, and all but about 200 are Roman Catholic. The municipality has a pre-school, an elementary school and a telesecundaria, as well as a rural medical clinic, a tianguis market, and a Dominican church. The church dates from the early colonial era and has a number of excellent santos, statues of saints, many done in fine polychrome and some dating to the 16th and 17th centuries.
Santos used in Holy Week observances
A very old Señor de la Misericordia given a modern loincloth.