Saripidem

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Saripidem
Saripidem.svg
Systematic (IUPAC) name
N-[(2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3-yl)methyl]-N-methylbutanamide
Clinical data
Legal status
?
Identifiers
CAS number 103844-86-6 N
ATC code None
PubChem CID 3058746
ChemSpider 2319846 YesY
UNII 0J6174G60N YesY
ChEMBL CHEMBL73416 YesY
Chemical data
Formula C19H20ClN3O 
Mol. mass 341.835 g/mol
 N (what is this?)  (verify)

Saripidem is a sedative and anxiolytic drug in the imidazopyridine family, which is related to the better known drugs zolpidem and alpidem.

Saripidem has a similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties, but its chemical structure is quite different from that of the benzodiazepine drugs, and saripidem is described as a nonbenzodiazepine.

The mechanism of action by which saripidem produces its sedative and anxiolytic effects is by modulating the benzodiazepine binding site on GABAA receptors, however unlike many older GABAA agonists, saripidem is highly subtype selective and binds primarily to the ω1 subtype.[1]

References[edit]

  1. ^ Sanger DJ (1995). "Behavioural effects of novel benzodiazepine (omega) receptor agonists and partial agonists: increases in punished responding and antagonism of the pentylenetetrazole cue". Behavioural Pharmacology 6 (2): 116–126. doi:10.1097/00008877-199503000-00003. PMID 11224318.