Sarmazenil

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Sarmazenil
Sarmazenil.png
Systematic (IUPAC) name
Ethyl 7-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 78771-13-8 YesY
ATCvet code QV03AB91
PubChem CID 71231
ChemSpider 64366 N
UNII F84AE7X24P YesY
ChEMBL CHEMBL46547 N
Chemical data
Formula C15H14ClN3O3 
Mol. mass 319.743 g/mol
 N (what is this?)  (verify)

Sarmazenil (Ro15-3505) is a drug from the benzodiazepine family. It acts as a partial inverse agonist of benzodiazepine receptors,[1] meaning that it causes the opposite effects to most benzodiazepine drugs, and instead acts as an anxiogenic and convulsant. It is used in veterinary medicine to reverse the effects of benzodiazepine sedative drugs in order to rapidly re-awaken anesthetized animals.[2][3][4]


See also[edit]

References[edit]

  1. ^ López-Romero B, Evrard G, Durant F, Sevrin M, George P (1998). "Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors): comparison with bretazenil and flumazenil". Bioorganic and Medicinal Chemistry 6 (10): 1745–57. doi:10.1016/S0968-0896(98)00117-5. PMID 9839004. 
  2. ^ Henke J, Roberts U, Otto K, Lendl C, Matis U, Brill T, Erhardt W (1996). "Clinical investigations of an i.m. combination anesthesia with fentanyl / climazolam / xylazine and postoperative i.v. antagonism with naloxone / sarmazenil / yohimbine in guinea pigs". Tierärztliche Praxis (in German) 24 (1): 85–7. PMID 8720962. 
  3. ^ Janovsky M, Tataruch F, Ambuehl M, Giacometti M (2000). "A Zoletil-Rompun mixture as an alternative to the use of opioids for immobilization of feral red deer". Journal of Wildlife Diseases 36 (4): 663–9. doi:10.7589/0090-3558-36.4.663. PMID 11085427. 
  4. ^ Walzer C, Huber C (2002). "Partial antagonism of tiletamine-zolazepam anesthesia in cheetah". Journal of Wildlife Diseases 38 (2): 468–72. doi:10.7589/0090-3558-38.2.468. PMID 12038151.