Sasabe (O'odham: Ṣaṣawk) is a small unincorporated border community in the Altar Valley of southern Pima County, Arizona, United States. It hosts a little-used United States–Mexico border crossing. Sasabe, Arizona is much smaller than its sister community, El Sásabe, Sonora, which is known for its burnt-adobe brickyards.
On average, 165 cars, trucks, or pedestrians per day passed through the Sasabe port of entry in 2011. 
Sasabe is best known for its historic Rancho de la Osa guest ranch, formerly the headquarters of a three million acre (12,000 km²) Spanish land grant. Some ranch buildings reportedly date to the late 17th century. The guest ranch opened in 1921. Guests have included Presidents Franklin Roosevelt and Lyndon Johnson. 
Much of the area north and east of Sasabe is within the Buenos Aires National Wildlife Refuge. In 2006, 3,500 acres (14 km2) of the refuge that border Mexico east of Sasabe were closed to public entry due to problems with smugglers and unauthorized border crossings. 
- Magahern, Jimmy (December 2013). "Arizona’s Smallest Town". The Valley Times (Scottsdale, Arizona: Times Publications).
- Sasabe at Google maps
- Buenos Aires National Wildlife Refuge