Highway 46 is a highway in the Canadian province of Saskatchewan. It runs from the Ring Road at Regina to Highways 1 and 364 near Balgonie. Highway 46 is about 29 km (18 mi.) long. The highway used to only exist as a gravel grid road from Regina to Pilot Butte. In the early 1990s the Highway was paved completely and extended from Pilot Butte to Balgonie.
The highway is known as McDonald Street within Regina city limits.