Highway 46 is a highway in the Canadian province of Saskatchewan. It runs from the Ring Road at Regina to Highways 1 and 364 near Balgonie. Highway 46 is about 29 km (18 mi.) long. The highway used to only exist as a gravel grid road from Regina to Pilot Butte. In the early 1990s the Highway was paved completely and extended from Pilot Butte to Balgonie, and it was again re-paved in the summer of 2014.
The highway is known as McDonald Street within Regina city limits.