Satavaptan

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Satavaptan
Satavaptan structure.svg
Systematic (IUPAC) name
N-(tert-butyl)-4-{[(1s,4s)-5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl]sulfonyl}-3-methoxybenzamide
Clinical data
Legal status ?
Identifiers
CAS number 185913-78-4
ATC code None
PubChem CID 9810773
UNII AJS8S3P31H YesY
Chemical data
Formula C33H45N3O8S 
Mol. mass 643.789
 YesY (what is this?)  (verify)

Satavaptan (INN; codenamed SR121463, planned tradename Aquilda) is a vasopressin-2 receptor antagonist[1] undergoing research for the treatment of hyponatremia. It is also being studied for the treatment of ascites.[2]

It was developed by Sanofi-Aventis. As of 2008, it is under regulatory review in the European Union.

References[edit]

  1. ^ Soupart A, Gross P, Legros JJ et al. (November 2006). "Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist". Clin J Am Soc Nephrol 1 (6): 1154–1160. doi:10.2215/CJN.00160106. PMID 17699341. 
  2. ^ Ginès P, Wong F, Watson H, Milutinovic S, Ruiz Del Arbol L, Olteanu D (February 2008). "Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial". Hepatology 48 (1): 204–213. doi:10.1002/hep.22293. PMID 18508290.