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Satavaptan structure.svg
Systematic (IUPAC) name
Clinical data
Legal status
CAS number 185913-78-4 YesY
ATC code None
PubChem CID 9810773
ChemSpider 32699105 N
Chemical data
Formula C33H45N3O8S 
Molecular mass 643.789
 N (what is this?)  (verify)

Satavaptan (INN; codenamed SR121463, planned tradename Aquilda) is a vasopressin-2 receptor antagonist[1] undergoing research for the treatment of hyponatremia. It is also being studied for the treatment of ascites.[2]

It was developed by Sanofi-Aventis. As of 2008, it is under regulatory review in the European Union.


  1. ^ Soupart A, Gross P, Legros JJ et al. (November 2006). "Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist". Clin J Am Soc Nephrol 1 (6): 1154–1160. doi:10.2215/CJN.00160106. PMID 17699341. 
  2. ^ Ginès P, Wong F, Watson H, Milutinovic S, Ruiz Del Arbol L, Olteanu D (February 2008). "Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial". Hepatology 48 (1): 204–213. doi:10.1002/hep.22293. PMID 18508290.