The song was featured as the opening song on the Smallville compilation CD: Smallville: The Talon Mix (2003). The Season 1 finale, titled "Tempest", features Remy Zero appearing at a high school dance and performing "Save Me" and "Perfect Memory (I'll Remember You)".
The music video for "Save Me", directed by Phil Harder, was filmed in Minneapolis, Minnesota and features clips of downtown Minneapolis, Minnesota State Fairgrounds and of the bridges along the Mississippi River, including the I-35W Mississippi River bridge which collapsed in August 2007. In the music video, Cinjun Tate is different from everyone else. Everyone around him walks in reverse as well as the cars. The band performs inside a giant room with background projections of unrelated images. In one case, there is a lizard.