Erickson was born in Long Beach, California, and began his professional career, after being drafted by the NY Mets in 1986, Houston Astros in 1987, and Toronto Blue Jays in 1988, in 1989 when he was drafted by the Minnesota Twins in the 4th round of the amateur draft. After 27 minor league starts, Erickson rose to the major leagues in his second season of professional baseball in 1990 direct from Class AA Orlando Sun Rays, a season in which he finished with a record of 8-4. After posting a record of 12-2 with a 1.39 ERA in the first half of the 1991 season, including being awarded the American League Pitcher of the Month award for May, Erickson won 20 games in his first full season and finished second to Roger Clemens in the American League Cy Young Award. During the Minnesota Twins1991, World Series winning season, Erickson led the majors in wins with a record of 20-8. After giving up the most hits in the Major Leagues in 1993, he became the third Twins pitcher to throw a no-hitter on April 27, 1994, against the Milwaukee Brewers. It was the first no-hitter in the Metrodome.
Erickson remained with the Twins until 1995 when he was traded to the Baltimore Orioles, earning a peak annual salary of $6,620,921. He later signed a five-year, $32-million contract with Baltimore through 2003. At the end of his contract, he joined the New York Mets and then was traded to the Texas Rangers in 2004.
He was in the starting rotation for the Los Angeles Dodgers in 2005. Erickson signed a deal with the New York Yankees on February 16, 2006. Erickson was released by the Yankees on June 19 and retired from baseball at the beginning of the 2007 season.
Scott Erickson was a groundball pitcher, leading the league five times in most double plays, and is in the Top 5 alltime in groundball to flyout ratio. Erickson was highly involved in sports even during high school; while he attended Homestead High School in Cupertino, California he played third base, soccer and football. After completing his secondary education, he graduated from San Jose City College in 1988 and then majored in accounting at the University of Arizona. Scott was inducted into the Arizona Wildcat Hall of Fame after just one year of pitching at the university. Erickson set a school record for wins with an 18-3 record, as he led the country in wins, innings pitched, and complete games(14). Those impressive numbers earned him a unanimous First Team All-American honor. His teammates at Arizona included Trevor Hoffman, Kevin Long, and J. T. Snow. On February 3, 2004, Erickson married television reporter and model Lisa Guerrero. Erickson started a production company called "HomeTeam Productions". Erickson was an executive producer for the movie A Plumm Summer which came out to theaters on April 25, 2008.