Lucas co-founded Local H in Zion, Illinois, in 1987 with high school friend Joe Daniels (drums), with Matt Garcia (bass) joining in 1990. Garcia left the band in 1993, and Lucas added bass pickups to his guitar to compensate; Daniels left the band in 1999, and was replaced by Brian St. Clair, leaving Lucas as the only remaining original band member. Local H has released several albums, and released a cover record in 2010. Lucas is also a member of the electronic band, The Prairie Cartel, and has released three albums through his solo project, Scott Lucas and the Married Men, which he founded in 2010  He was also in a cover band called The Cold Space, featuring Randy Payne and Tom Szidon from Scott Lucas and the Married Men.
In February 2013, Lucas was attacked and robbed after playing a show in Russia. During the attack, Lucas lost his voice and sustained damage to his vocal cords. Lucas quickly regained his voice, but Local H was forced to cancel a string of concerts as a precaution as his vocal cords healed. Lucas has since returned to touring with Local H and The Married Men.