The league came into existence in time for the 2006–07 season, replacing the older regional setup (see here). It was expanded for the start of the 2013–14 season by absorbing the more southerly clubs from the dissolved East Region Central Division as part of league reconstruction the in East Region.
Armadale Thistle won the 2008–09 championship and were promoted to the Premier League. None of the Premier Division teams relegated in this season will replace Armadale (due to geography). However, a bid by Spartans FC to admit their second XI into the Scottish Junior Football Association was accepted at AGM and this team will be a member of the South Division for season 2009–10.