Scutellaria baicalensis
| Scutellaria baicalensis | |
|---|---|
 |
|
| Scientific classification | |
| Kingdom: | Plantae |
| (unranked): | Angiosperms |
| (unranked): | Eudicots |
| (unranked): | Asterids |
| Order: | Lamiales |
| Family: | Lamiaceae |
| Genus: | Scutellaria |
| Species: | S. baicalensis |
| Binomial name | |
| Scutellaria baicalensis Georgi[1] |
|
| Synonyms | |
Scutellaria baicalensis (or Baikal Skullcap, as opposed to Scutellaria lateriflora, a Skullcap native to North America) is a species of flowering plant in the Lamiaceae family.
Contents |
[edit] Traditional Chinese medicine
It is one of the 50 fundamental herbs used in traditional Chinese medicine, where it has the name huáng qín (Chinese: 黄芩). It has been reported to have anti-asthmatic, antifungal, antioxidative, and anti-inflammatory activities.[2]
[edit] Chemistry
Scutellaria baicalensis Georgi contains wogonin, a flavone which was found in one study to have anxiolytic properties in mice at doses of 7.5 to 30 mg/kg, without exhibiting the sedative and muscle-relaxing properties of benzodiazepines.[3] It may have anti-tumor potential.[4][5]
It also contains baicalin, another flavone. Baicalein induces apoptosis in pancreatic cancer cells through down-regulation of the anti-apoptotic Mcl-1 protein in vitro .[6]
[edit] Etymology confusion
It is important to note the Latin name of the Skullcap being used as there are over 200 varieties, some used for various ailments, each with varying degrees of effectiveness. Sometimes Scutellaria lateriflora (North American Skullcap) is mistaken for Scutellaria baicalensis (Baikal Skullcap). This confusion can result in the intake of the lateriflora variety which is often processed and contaminated with other plants with high enough levels of toxicity to be of concern.
[edit] See also
- Chinese herbology 50 fundamental herbs
[edit] References
- ^ a b "Scutellaria baicalensis information from NPGS/GRIN". USDA. http://www.ars-grin.gov/cgi-bin/npgs/html/taxon.pl?33424. Retrieved 2008-02-19.
- ^ Zhang XW, Li WF, Li WW, Ren KH, Fan CM, Chen YY, Shen YL "Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells". Pharm Biol. 2011 Mar;49(3):256-61
- ^ Hui KM, Huen MS, Wang HY, et al (November 2002). "Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi". Biochem. Pharmacol. 64 (9): 1415–24. doi:10.1016/S0006-2952(02)01347-3. PMID 12392823. http://linkinghub.elsevier.com/retrieve/pii/S0006295202013473.
- ^ Lin CC, Kuo CL, Lee MH, Lai KC, Lin JP, Yang JS, Yu CS, Lu CC, Chiang JH, Chueh FS, Chung JG.,"Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways". Int J Oncol. 2011 Jul;39(1):217-24
- ^ Gao J, Morgan WA, Sanchez-Medina A, Corcoran O"The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells." Toxicol Appl Pharmacol. 2011 Aug 1;254(3):221-8
- ^ Takahashi H, Chen MC, Pham H, Angst E, King JC, Park J, Brovman EY, Ishiguro H, Harris DM, Reber HA, Hines OJ, Gukovskaya AS, Go VL, Eibl G"Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells." Biochim Biophys Acta. 2011 Aug;1813(8):1465-74
[edit] External links
 |
Wikimedia Commons has media related to: Scutellaria baicalensis |
 |
Wikispecies has information related to: Scutellaria baicalensis |
- Scutellaria baicalensis List of Chemicals (Dr. Duke's Databases)
- Scutellaria baicalensis (Plants for a Future)
- Sung Mun Jung et al., "Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels", Arthritis Research & Therapy 2007, 9:R64 doi:10.1186/ar2222. Considers anti-inflammatory properties of dried roots from the species Angelica sinensis (Dong Quai), Acanthopanax senticosus (now known as Eleutherococcus senticosus, or Siberian Ginseng), and Scutellaria baicalensis (Baikal Skullcap).
 |
This Lamiaceae article is a stub. You can help Wikipedia by expanding it. |
