Nolin missed the first month of the 2013 baseball season with a groin injury suffered during spring training. On May 23, 2013, it was announced that Nolin would be called up to the Major Leagues to start on May 24, 2013 against the Baltimore Orioles. He was formally called up on May 24 when J. A. Happ was transferred to the 60-day disabled list. Nolin took the loss in his debut, pitching 11⁄3 innings and giving up 6 earned runs and one walk. He was optioned back to Double-A New Hampshire following the 10–6 loss. Nolin was ranked as the number 5 prospect in the Blue Jays organization on July 26, 2013, when the revised Top 100 Prospects list was released. Nolin was promoted to the Triple-A Buffalo Bisons on August 17.
Nolin was optioned to the Buffalo Bisons on March 16, 2014.