Since its debut in 2003, Second Life has become increasingly referred by various popular culture mediums, including literary, television, film and music. In addition, various significantly-popular personalities in such mediums have themselves used or employed Second Life for both their own works and for private purposes.
"Notre Seconde Vie" is a book from the French writer Alain Monnier which translates to "Our Second Life". The novel poses the question "will the Internet replace reading paperbound books one day?".
The 2007 novel Another Life by Peter Anghelides, based upon the television series Torchwood, features a Second Life-inspired virtual world called Second Reality. Although the literary version is far more advanced than the real Second Life, several features of the real-life Second Life are referenced, including the ability to customize avatars, and at one point in the novel a character is banished to an area similar to Second Life's punishment area, "The Corn Field".
In an episode of the CBS comedy 2 Broke Girls on January 20, 2014 Han Lee (Matthew Moy) stated he was to busy in Second Life to help Caroline (Beth Behrs) when she was at home scared. Han stated that his Second Life online wife was having a baby.
Second Life was featured prominently, and used as a tool to locate a suspect, in the CSI: NY episode "Down the Rabbit Hole", which aired on October 24, 2007. It was also featured in the episode "DOA For a Day" (aired 2 April 2008).
Dwight Schrute from the US television series The Office is an avid Second Life resident; this was featured prominently in the October 25, 2007 episode "Local Ad". Dwight has an avatar named 'Dwight Shelford' and creates a virtual world within Second Life named Second Second Life. Jim Halpert is also seen in Second Life later in the episode, and he claims his character is "just to keep tabs on Dwight"; however, Pam Beesly comments on the detail in his character and notes it must have taken him quite some time to make it.
In an episode of the CBS drama Ghost Whisperer, Melinda Gordon experiences a similar online world, at one point pulling an avatar out of her computer at the shop as the user's ghost; she gets to know the local equivalent of Second Life while determining the avatar's true identity.
The CBC program the fifth estate, in an episode entitled "Strangers in Paradise," first aired January 28, 2009, documented two cases of families being damaged after a spouse became obsessed with Second Life. In each case a spouse formed such deep emotional and cyber-sexual relationships with another Second Life player that it resulted in their leaving their real family to join the person they had met and bonded with in Second Life.
The episode "Social Networking" on Current's "SuperNews!" involved a Second Life character with one eye and a multi-pitched psychic-esque "echo" voice, alongside MySpace, Facebook and Friendster characters.
Duran Duran were among the first artists to join the metaverse, and they subsequently wrote their "Zoom In" song with hip-hop mogul Timbaland, clearly pointing about the Second Life experience.
Redzone were credited by Wired and Reuters as the first band to tour in Second Life in Feb. 2007, followed by Beyond the void as the first official rock band touring in second life (open PR, Mar. 2007).
The Italian singer Irene Grandi figured in her musical video "Bruci la città" some scenes of Second Life gaming.
In an episode of The Suite Life on Deck,Woody is seen to play second life and forms a relationship from doing so with another crew member.
In October 2013, singer-songwriter Liza Fox released a machinima music video "You Turn Me On" filmed by Pia Klaar based on the song of the same title in the 3D virtual world Second Life.
A Second Life girl, caLLie cLine, was chosen to represent Second Life Girls at #95 on the "Top 100 Hottest Females of 2007" in Maxim.
Second Life is also parodied in the webcomic Kevin and Kell, in the form of an MMORPG called 9th Life.
Second Life is parodied by the website Get a First Life by Darren Barefoot, extolling the virtues of meatspace/real life. Material from the site includes false links to such topics as "Go Outside - Membership is Free" and "Fornicate Using Your Actual Genitals." Linden Lab proved that they had a sense of humor when Darren received, instead of a cease and desist, a Proceed and Permit letter.
Kelly Services, an employment agency, features Second Life in its "break room" for temporary employees.