Secretin receptor

Secretin receptor
Identifiers
Symbols	SCTR; SR
External IDs	OMIM: 182098 HomoloGene: 68290 IUPHAR: secretin receptor GeneCards: SCTR Gene
Gene Ontology Molecular function • secretin receptor activity Cellular component • plasma membrane • plasma membrane • integral to plasma membrane Biological process • G-protein coupled receptor protein signaling pathway • digestion • excretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6344	n/a
Ensembl	ENSG00000080293	n/a
UniProt	P47872	n/a
RefSeq (mRNA)	NM_002980.2	n/a
RefSeq (protein)	NP_002971.2	n/a
Location (UCSC)	Chr 2: 120.2 – 120.28 Mb	n/a
PubMed search	[1]	n/a

Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the class B GPCR subfamily.

Interactions

Secretin receptor has been shown to interact with Pituitary adenylate cyclase activating peptide.

Further reading

• Ulrich CD, Holtmann M, Miller LJ (1998). "Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors.". Gastroenterology 114 (2): 382–97. doi:10.1016/S0016-5085(98)70491-3. PMID 9453500. 
• Felley CP, Qian JM, Mantey S, et al. (1993). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release.". Am. J. Physiol. 263 (6 Pt 1): G901–7. PMID 1335692. 
• Ishihara T, Nakamura S, Kaziro Y, et al. (1991). "Molecular cloning and expression of a cDNA encoding the secretin receptor.". EMBO J. 10 (7): 1635–41. PMC 452832. PMID 1646711. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452832. 
• Robberecht P, De Neef P, Waelbroeck M, et al. (1988). "Secretin receptors in human pancreatic membranes.". Pancreas 3 (5): 529–35. doi:10.1097/00006676-198810000-00004. PMID 3186683. 
• Chow BK (1995). "Molecular cloning and functional characterization of a human secretin receptor.". Biochem. Biophys. Res. Commun. 212 (1): 204–11. doi:10.1006/bbrc.1995.1957. PMID 7612008. 
• Patel DR, Kong Y, Sreedharan SP (1995). "Molecular cloning and expression of a human secretin receptor.". Mol. Pharmacol. 47 (3): 467–73. PMID 7700244. 
• Holtmann MH, Hadac EM, Miller LJ (1995). "Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors.". J. Biol. Chem. 270 (24): 14394–8. doi:10.1074/jbc.270.24.14394. PMID 7782300. 
• Jiang S, Ulrich C (1995). "Molecular cloning and functional expression of a human pancreatic secretin receptor.". Biochem. Biophys. Res. Commun. 207 (3): 883–90. doi:10.1006/bbrc.1995.1268. PMID 7864894. 
• Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor.". Biochem. Biophys. Res. Commun. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245. 
• Mark HF, Chow BK (1996). "Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry.". Genomics 29 (3): 817–8. doi:10.1006/geno.1995.9922. PMID 8575789. 
• Vilardaga JP, di Paolo E, de Neef P, et al. (1996). "Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin.". Biochem. Biophys. Res. Commun. 218 (3): 842–6. doi:10.1006/bbrc.1996.0150. PMID 8579602. 
• Chow BK (1998). "Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor.". Receptors & signal transduction 7 (3): 143–50. PMID 9440501. 
• Shetzline MA, Premont RT, Walker JK, et al. (1998). "A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor.". J. Biol. Chem. 273 (12): 6756–62. doi:10.1074/jbc.273.12.6756. PMID 9506976. 
• Ho PK, Fong RS, Kai HS, et al. (1999). "The human secretin receptor gene: genomic organization and promoter characterization.". FEBS Lett. 455 (3): 209–14. doi:10.1016/S0014-5793(99)00864-9. PMID 10437774. 
• Pang RT, Ng SS, Cheng CH, et al. (1999). "Role of N-linked glycosylation on the function and expression of the human secretin receptor.". Endocrinology 140 (11): 5102–11. doi:10.1210/en.140.11.5102. PMID 10537138. 
• Chan KY, Pang RT, Chow BK (2001). "Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor.". Endocrinology 142 (9): 3926–34. doi:10.1210/en.142.9.3926. PMID 11517171. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Pang RT, Lee LT, Ng SS, et al. (2004). "CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene.". Mol. Endocrinol. 18 (2): 471–83. doi:10.1210/me.2003-0245. PMID 14645499. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 

External links

• IUPHAR GPCR Database - Secretin receptor
• MeSH secretin+receptor