Secretin receptor

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Secretin receptor
Identifiers
Symbols SCTR ; SR
External IDs OMIM182098 HomoloGene68290 IUPHAR: secretin receptor ChEMBL: 1925 GeneCards: SCTR Gene
RNA expression pattern
PBB GE SCTR 210382 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6344 319229
Ensembl ENSG00000080293 ENSMUSG00000026387
UniProt P47872 Q5FWI2
RefSeq (mRNA) NM_002980 NM_001012322
RefSeq (protein) NP_002971 NP_001012322
Location (UCSC) Chr 2:
120.2 – 120.28 Mb
Chr 1:
120.01 – 120.06 Mb
PubMed search [1] [2]

Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the class B GPCR subfamily.[1]

Interactions[edit]

Secretin receptor has been shown to interact with Pituitary adenylate cyclase activating peptide.[2]

References[edit]

  1. ^ Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Recept. Channels 8 (3–4): 189–200. doi:10.1080/10606820213686. PMID 12529936. 
  2. ^ Felley, C P; Qian J M; Mantey S; Pradhan T; Jensen R T (Dec 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. (UNITED STATES) 263 (6 Pt 1): G901–7. ISSN 0002-9513. PMID 1335692. 

Further reading[edit]

  • Ulrich CD, Holtmann M, Miller LJ (1998). "Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors". Gastroenterology 114 (2): 382–97. doi:10.1016/S0016-5085(98)70491-3. PMID 9453500. 
  • Felley CP, Qian JM, Mantey S, et al. (1993). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. 263 (6 Pt 1): G901–7. PMID 1335692. 
  • Ishihara T, Nakamura S, Kaziro Y, et al. (1991). "Molecular cloning and expression of a cDNA encoding the secretin receptor". EMBO J. 10 (7): 1635–41. PMC 452832. PMID 1646711. 
  • Robberecht P, De Neef P, Waelbroeck M, et al. (1988). "Secretin receptors in human pancreatic membranes". Pancreas 3 (5): 529–35. doi:10.1097/00006676-198810000-00004. PMID 3186683. 
  • Chow BK (1995). "Molecular cloning and functional characterization of a human secretin receptor". Biochem. Biophys. Res. Commun. 212 (1): 204–11. doi:10.1006/bbrc.1995.1957. PMID 7612008. 
  • Patel DR, Kong Y, Sreedharan SP (1995). "Molecular cloning and expression of a human secretin receptor". Mol. Pharmacol. 47 (3): 467–73. PMID 7700244. 
  • Holtmann MH, Hadac EM, Miller LJ (1995). "Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors". J. Biol. Chem. 270 (24): 14394–8. doi:10.1074/jbc.270.24.14394. PMID 7782300. 
  • Jiang S, Ulrich C (1995). "Molecular cloning and functional expression of a human pancreatic secretin receptor". Biochem. Biophys. Res. Commun. 207 (3): 883–90. doi:10.1006/bbrc.1995.1268. PMID 7864894. 
  • Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochem. Biophys. Res. Commun. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245. 
  • Mark HF, Chow BK (1996). "Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry". Genomics 29 (3): 817–8. doi:10.1006/geno.1995.9922. PMID 8575789. 
  • Vilardaga JP, di Paolo E, de Neef P, et al. (1996). "Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin". Biochem. Biophys. Res. Commun. 218 (3): 842–6. doi:10.1006/bbrc.1996.0150. PMID 8579602. 
  • Chow BK (1998). "Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor". Receptors & signal transduction 7 (3): 143–50. PMID 9440501. 
  • Shetzline MA, Premont RT, Walker JK, et al. (1998). "A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor". J. Biol. Chem. 273 (12): 6756–62. doi:10.1074/jbc.273.12.6756. PMID 9506976. 
  • Ho PK, Fong RS, Kai HS, et al. (1999). "The human secretin receptor gene: genomic organization and promoter characterization". FEBS Lett. 455 (3): 209–14. doi:10.1016/S0014-5793(99)00864-9. PMID 10437774. 
  • Pang RT, Ng SS, Cheng CH, et al. (1999). "Role of N-linked glycosylation on the function and expression of the human secretin receptor". Endocrinology 140 (11): 5102–11. doi:10.1210/en.140.11.5102. PMID 10537138. 
  • Chan KY, Pang RT, Chow BK (2001). "Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor". Endocrinology 142 (9): 3926–34. doi:10.1210/en.142.9.3926. PMID 11517171. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Pang RT, Lee LT, Ng SS, et al. (2004). "CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene". Mol. Endocrinol. 18 (2): 471–83. doi:10.1210/me.2003-0245. PMID 14645499. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 

External links[edit]