Segmental duplication

From Wikipedia, the free encyclopedia
Jump to: navigation, search

Segmental duplications (SDs) are segments of DNA with near-identical sequence.[1]

Segmental duplications give rise to low copy repeats (LCRs) and are believed to have played a role in creating new primate genes as reflected in human genetic variation. In humans, chromosomes Y and 22 have the greatest proportion of SDs: 50.4% and 11.9% respectively.[2]

Detection method[edit]

The two widely accepted methods for SD detection are whole genome assembly comparison (WGAC) and whole genome shotgun sequence detection (WSSD).

See also[edit]

References[edit]

  1. ^ Genome-wide detection of segmental duplications
  2. ^ Bailey, Jeffrey A.; Eichler, EE (2006). "Primate segmental duplications: crucibles of evolution, diversity and disease". Nature Reviews Genetics 7 (7): 552–64. doi:10.1038/nrg1895. PMID 16770338.